Triclocarban-3-4-4-Trichlorocarbanilide-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETriclocarbanCat. No.: HY-B1805CAS No.: 101-20-2Synonyms: 3,4,4-Trichlorocarbanilide分式: CHClNO分量: 315.58作靶點: Bacterial作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 DMSO : 150 m

2、g/mL (475.32 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.1688 mL 15.8438 mL 31.6877 mL5 mM 0.6338 mL 3.1688 mL 6.3375 mL10 mM 0.3169 mL 1.5844 mL 3.1688 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Triclocarban于個 潔品中的抗菌劑。IC5

3、0 & Target Bacterial 1體外研究Triclocarban at 300 nM potentiates the cytotoxicity of 300 M H2O2 in rat thymocytes. 300 nM triclocarban1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEitself does not increase the population of death cells, it facilitates the process of cell death induced by H2O2,resultin

4、g in further increase in the population of dead cells 1. Triclocarban exertes estrogenic activities byinducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ER expression at both the mRNA an

5、d protein levelsin the MCF-7 cells 2.體內研究 Triclocarban is absorbed significantly from soap used during showering in human subjects and that its Cmaxin their whole blood ranges from 23 nM to 530 nM 1. Gestational triclocarban exposure does not affect theability of dams to carry offspring to term but

6、triclocarban exposure during lactation has adverseconsequences on the survival of offspring 3.PROTOCOLAnimal Rats: Sprague Dawley rats are provided control, 0.2% weight/weight (w/w), or 0.5% w/w triclocarban -Administration 3 supplemented chow through a series of 3 experiments that limited exposure

7、to critical growth periods:gestation, gestation and lactation, or lactation only (cross-fostering) to determine the susceptible windows ofexposure for developmental consequences 3.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Kanbara Y, e

8、t al. Nanomolar concentration of triclocarban increases the vulnerability of rat thymocytes to oxidative stress. J Toxicol Sci.2013 Feb;38(1):49-55.2. Huang H, et al. The in vitro estrogenic activities of triclosan and triclocarban. J Appl Toxicol. 2014 Sep;34(9):1060-7.3. Kennedy RC, et al. Early life triclocarban exposure during lactation affects neonate rat survival. Reprod Sci. 2015 Jan;22(1):75-89.McePdfHeightCaution: Product has not been fully validated for medical applica