ML367 _ATAD5 Stabilization 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEML367Cat. No.: HY-122198CAS No.: 381168-77-0分式: CHFN分量: 334.32作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 125 mg/mL (373.89 mM)* means soluble, but saturation unkn

2、own.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.9911 mL 14.9557 mL 29.9115 mL5 mM 0.5982 mL 2.9911 mL 5.9823 mL10 mM 0.2991 mL 1.4956 mL 2.9911 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以

3、下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.22 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (6.22 mM); Suspended solution; Need ultrasonic3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Sma

4、ll Molecules 您邊的抑制劑師www.MedChemESolubility: 2.08 mg/mL (6.22 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 ML367種 ATPase 家族 AAA 結(jié)構(gòu)域蛋 5 (ATAD5) 穩(wěn)定的有效抑制劑，作為個(gè)探針分，具有低摩爾抑制濃度。ML367 阻斷 DNA 的修復(fù)通路，抑制般的 DNA 損傷反應(yīng)，包括應(yīng)對(duì)紫外照射產(chǎn)的 RPA32 和CHK1 的磷酸化 1。IC50 & Target ATAD5 1體外研究 ML367 (0-40 M, 16 hours) inhibits FLAG-ATAD5 s

5、tabilization in HEK293T cells in the presence or absenceof 20 M 5-FUrd 1.Western Blot Analysis 1Cell Line: HEK293T cellsConcentration: 0-40 M in the presence or absence of 20 M 5-FurdIncubation Time: 16 hoursResult: Inhibited the increased ATAD5 protein levels induced by 5-Furd.REFERENCES1. Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379