Licoricidin _Apoptosis Activator - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELicoricidinCat. No.: HY-N3387CAS No.: 30508-27-1分式: CHO分量: 424.53作靶點: Apoptosis; NF-B; Akt; MMP; ROS作通路: Apoptosis; NF-B; PI3K/Akt/mTOR; MetabolicEnzyme/Protease; Protein Tyrosine Kinase/RTK儲存式: Please store the product under th

2、e recommended conditions inthe COA.BIOLOGICAL ACTIVITY物活性 Licoricidin (LCD) 從草 Glycyrrhiza uralensis Fisch 中分離，具有抗癌活性。Licoricidin (LCD) 通過誘導(dǎo)周 期停滯，誘導(dǎo)細胞凋亡 (apoptosis) 和噬 (autophagy)， 種對抗結(jié)直腸癌的潛在化學(xué)預(yù)防或化學(xué)治療劑。Licoricidin (LCD) 通過抑制腫瘤管成和淋巴管成以及腫瘤組織局部微環(huán)境的變化抑制肺轉(zhuǎn)移。Licoricidin(LCD) 通過體外和體內(nèi) Akt 和 NF-B 途徑的失活，增強吉西他

3、濱誘導(dǎo)的瘤 (OS) 細胞的細胞毒性。Licoricidin (LCD) 通過 ROS 除阻斷 UVA 誘導(dǎo)的光化，限制 MMP-1 的活性，被認為 新的局部應(yīng)的抗衰制劑中的活性成分。體外研究Licoricidin (LCD) (0-20 M; 24 hours) dose-dependently inhibits the viability of colon cancer cell lines withvarious pathological and genetic characters, namely SW480, HCT116, SW620 and LoVo cells, with IC

4、50values of 7.2, 5.4, 4.5 and 5.1 M, respectively 1.Licoricidin (LCD) (0-20 M; 0-12 hours) induces cellapoptosis was accompanied with the activation of caspase-3 by cleavage in a time- and dose-dependentmanner 1.Licoricidin (LCD) (0-20 M; 0-12 hours) induces autophagy of SW480 cells, increases thecl

5、eavage of LC3-I to LC3-II and the degradation of p62 in a time and dose dependent manner 1.Licoricidin(LCD) (0-5 g/ml; 18 hours) inhibits cell migration, MMP-9 secretion, and VCAM expression in 4T1 cells 2.Cell Viability Assay 1Cell Line: SW480, HCT116, SW620 and LoVo cellsConcentration: 0-20 MIncub

6、ation Time: 24 hours1/3 Master of Small Molecules 您邊的抑制劑師www.MedChemEResult: Decreased colon cancer cell lines viability.Western Blot Analysis 1Cell Line: SW480 cellsConcentration: 0 M, 2.5 M, 5 M, 10 M, 20 MIncubation Time: 0 hours, 1 hour, 3 hours, 6 hours, 12 hoursResult: Induced cell apoptosis.體

7、內(nèi)研究 Licoricidin (LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 15 days) significantly inhibited thegrowth of SW480 xenografts in nude mice with an inhibitory rate of 43.5% 1.Licoricidin (LCD)(intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days) reduces pulmonary met

8、astasis and theexpression of CD45, CD31, HIF-1, iNOS, COX-2, and VEGF-A in tumor tissues, additionally, decreasesprotein expression of VEGF-R2, VEGF-C, VEGF-R3, and LYVE-1 in tumor tissues of licoricidin-treated mice2.Animal Model: SW480 xenografted tumor growth in nude mice 1Dosage: 5, 10, or 20 mg

9、/kgAdministration: Intraperitoneal injection; once daily; 15 daysResult: Decreased tumor volumes.Animal Model: BALB/c mouse orthotopic model 2Dosage: 5, 10, or 20 mg/kgAdministration: Intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 daysResult: Inhibited Lung Metastasis of 4T1 Murine Ma

10、mmary Carcinoma cells.REFERENCES1. Ji S, et al. Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest,apoptosis and autophagy. Toxicol Appl Pharmacol. 2017 Jul 1;326:25-33.2. Park SY, et al. Licoricidin, an Active Compound in the

11、 Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1Murine Mammary Carcinoma Cells. Int J Mol Sci. 2016 Jun 14;17(6).3. Wang Y, et al. Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-B signalpathways. Chem Biol Interact. 2018 Jun 25;290:44-51.4. Kim KJ, et al. Licoricidin, an isoflavonoid isolated from Glycyrrhiza uralensis Fisher, prevents UVA-induced photoaging of human dermalfibroblasts. Int J Cosmet Sci. 2017 Apr;39(2):133-140.2/3 Master of Small Molecules 您邊的抑制劑師www.MedChemEMcePdfHeightCaution: Pr