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1、 HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html Target HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html Protein HYPERLINK https:/www.MedChemE/Targets/

2、Target Protein Ligand-Linker Conjugate.html HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html Ligand-Linker HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.h

3、tml ConjugatesTarget Protein Ligand-Linker Conjugate incorporates a ligand for the target protein and a linker. When binding to an E3 ligaseligand, the conjugate will be a PROTAC with ability to induce ubiquitylation and subsequent degradation the protein of interest.Target proteins are usually prot

4、eins whose overexpression or accumulation may play important roles in the progress of diseases.Numbers of PROTACs have been developed to degrade kinases, transcription factors, epigenetic tools and E3 ligase themselves.The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to

5、over 20-carbon, and the commonly used linkersin the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html Target HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html H

6、YPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html Protein HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html Ligand-Linker HYPERLINK https:/www.MedChemE/Tar

7、gets/Target Protein Ligand-Linker Conjugate.html HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html Conjugates HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate.html HYPERLINK https:/www.MedChemE/Targets/Target Protein Ligand-Linker Conjugate

8、.html Chemicals HYPERLINK https:/www.MedChemE/bms-1166-n-piperidine-co-n-piperazine.html BMS-1166-N-piperidine-CO-N-piperazine HYPERLINK https:/www.MedChemE/bms-1166-n-piperidine-co-n-piperazine.html HYPERLINK https:/www.MedChemE/brd4-ligand-linker-conjugate-1.html BRD4 HYPERLINK https:/www.MedChemE

9、/brd4-ligand-linker-conjugate-1.html HYPERLINK https:/www.MedChemE/brd4-ligand-linker-conjugate-1.html ligand-Linker HYPERLINK https:/www.MedChemE/brd4-ligand-linker-conjugate-1.html HYPERLINK https:/www.MedChemE/brd4-ligand-linker-conjugate-1.html Conjugate HYPERLINK https:/www.MedChemE/brd4-ligand

10、-linker-conjugate-1.html HYPERLINK https:/www.MedChemE/brd4-ligand-linker-conjugate-1.html 1Cat. No.: HY-131386 Cat. No.: HY-132943BMS-1166-N-piperidine-CO-N-piperazine incorporatesa ligand for PD-1/PD-L1 immune checkpoint, and aPROTAC linker.BMS-1166-N-piperidine-CO-N-piperazine can be usedin the s

11、ynthesis of PROTAC PD-1/PD-L1 degrader-1(HY-131183).BRD4 ligand-Linker Conjugate 1 is a target proteinligand-linker conjugate that can be used in thesynthesis of PROTACs.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg

12、 HYPERLINK https:/www.MedChemE/desmorpholinyl-quizartinib-peg2-cooh.html Desmorpholinyl HYPERLINK https:/www.MedChemE/desmorpholinyl-quizartinib-peg2-cooh.html HYPERLINK https:/www.MedChemE/desmorpholinyl-quizartinib-peg2-cooh.html Quizartinib-PEG2-COOH HYPERLINK https:/www.MedChemE/desmorpholinyl-q

13、uizartinib-peg2-cooh.html HYPERLINK https:/www.MedChemE/dual-parp-egfr-ligand-for-protac.html Dual HYPERLINK https:/www.MedChemE/dual-parp-egfr-ligand-for-protac.html HYPERLINK https:/www.MedChemE/dual-parp-egfr-ligand-for-protac.html PARP HYPERLINK https:/www.MedChemE/dual-parp-egfr-ligand-for-prot

14、ac.html HYPERLINK https:/www.MedChemE/dual-parp-egfr-ligand-for-protac.html EGFR HYPERLINK https:/www.MedChemE/dual-parp-egfr-ligand-for-protac.html HYPERLINK https:/www.MedChemE/dual-parp-egfr-ligand-for-protac.html ligand HYPERLINK https:/www.MedChemE/dual-parp-egfr-ligand-for-protac.html HYPERLIN

15、K https:/www.MedChemE/dual-parp-egfr-ligand-for-protac.html for HYPERLINK https:/www.MedChemE/dual-parp-egfr-ligand-for-protac.html HYPERLINK https:/www.MedChemE/dual-parp-egfr-ligand-for-protac.html PROTACCat. No.: HY-131230 Cat. No.: HY-141486Desmorpholinyl Quizartinib-PEG2-COOH incorporatesa liga

16、nd for FLT-3, and a PEG-based PROTAC linker.Desmorpholinyl Quizartinib-PEG2-COOH can be usedin the synthesis of PROTAC FLT-3 degrader 1(HY-114323).Dual PARP EGFR ligand for PROTAC incorporates aligand for PARP and EGFR , and a PROTAC linker,which recruit E3 ligases (such as VHL, CRBN, MDM2,and IAP).

17、Purity: 95.09%Clinical Data: No Development ReportedSize: 50 mg, 250 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/err-alpha-ligand-linker-conjugates-1.html ERR HYPERLINK https:/www.MedChemE/err-alpha-ligand-linker-conjugates-1.html HYPERLINK https

18、:/www.MedChemE/err-alpha-ligand-linker-conjugates-1.html Ligand-Linker HYPERLINK https:/www.MedChemE/err-alpha-ligand-linker-conjugates-1.html HYPERLINK https:/www.MedChemE/err-alpha-ligand-linker-conjugates-1.html Conjugates HYPERLINK https:/www.MedChemE/err-alpha-ligand-linker-conjugates-1.html HY

19、PERLINK https:/www.MedChemE/err-alpha-ligand-linker-conjugates-1.html 1 HYPERLINK https:/www.MedChemE/err-alpha-ligand-linker-conjugates-1.html HYPERLINK https:/www.MedChemE/fak-ligand-linker-conjugate-1.html FAK HYPERLINK https:/www.MedChemE/fak-ligand-linker-conjugate-1.html HYPERLINK https:/www.M

20、edChemE/fak-ligand-linker-conjugate-1.html ligand-Linker HYPERLINK https:/www.MedChemE/fak-ligand-linker-conjugate-1.html HYPERLINK https:/www.MedChemE/fak-ligand-linker-conjugate-1.html Conjugate HYPERLINK https:/www.MedChemE/fak-ligand-linker-conjugate-1.html HYPERLINK https:/www.MedChemE/fak-liga

21、nd-linker-conjugate-1.html 1Cat. No.: HY-130499 Cat. No.: HY-44148ERR Ligand-Linker Conjugates 1 incorporates aligand for estrogen-related receptor alpha (ERR),and a PROTAC linker, which recruit E3 ligasesMDM2. ERR Ligand-Linker Conjugates 1 can beused in the synthesis of a series of PROTACs, suchas

22、 PROTAC ERRalpha Degrader-1 (HY-128838).FAK ligand-Linker Conjugate 1 incorporates aligand for FAK, and a PROTAC linker, whichrecruit E3 ligases (such as VHL, CRBN, MDM2, andIAP). FAK ligand-Linker Conjugate 1 can beextensively used for PROTAC-mediated proteindegradation.Purity: 96.70%Clinical Data:

23、 No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 98.28%Clinical Data:Size: 10 mM 1 mL, 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-1.html K-Ras HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-1.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker

24、-conjugate-1.html ligand-Linker HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-1.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-1.html Conjugate HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-1.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjuga

25、te-1.html 1 HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-1.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-2.html K-Ras HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-2.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-2.html ligand-Linker

26、HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-2.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-2.html Conjugate HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-2.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-2.html 2Cat. No.: HY-129775 C

27、at. No.: HY-129776K-Ras ligand-Linker Conjugate 1 incorporates aligand for K-Ras, and a PROTAC linker, whichrecruit E3 ligases (such as VHL, CRBN, MDM2, andIAP).K-Ras ligand-Linker Conjugate 2 incorporates aligand for K-Ras, and a PROTAC linker, whichrecruit E3 ligases (such as VHL, CRBN, MDM2, andI

28、AP).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-3.html K-Ras HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-3.html HYPERLINK https:/www.MedC

29、hemE/k-ras-ligand-linker-conjugate-3.html ligand-Linker HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-3.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-3.html Conjugate HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-3.html HYPERLINK https:/www.MedChemE/k-r

30、as-ligand-linker-conjugate-3.html 3 HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-3.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-4.html K-Ras HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-4.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjuga

31、te-4.html ligand-Linker HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-4.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-4.html Conjugate HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-4.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-4.htm

32、l 4Cat. No.: HY-130707 Cat. No.: HY-130822K-Ras ligand-Linker Conjugate 3 (Compound 001371)incorporates a ligand for K-Ras recruiting moiety,and a PROTAC linker, which recruit E3 ligases(such as VHL, CRBN, MDM2, and IAP).K-Ras ligand-Linker Conjugate 4 incorporates aligand for K-Ras recruiting moiet

33、y, and a PROTAClinker, which recruit E3 ligases (such as VHL,CRBN, MDM2, and IAP).Purity: 98%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg, 10 mgPurity: 95.06%Clinical Data: No Development ReportedSize: 100 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK h

34、ttps:/www.MedChemE/k-ras-ligand-linker-conjugate-5.html K-Ras HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-5.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-5.html ligand-Linker HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-5.html HYPERLINK https:/www.Me

35、dChemE/k-ras-ligand-linker-conjugate-5.html Conjugate HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-5.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-5.html 5 HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-5.html HYPERLINK https:/www.MedChemE/k-ras-ligand-

36、linker-conjugate-6.html K-Ras HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-6.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-6.html ligand-Linker HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-6.html HYPERLINK https:/www.MedChemE/k-ras-ligand-linker-conjugate-6.html Conjugate HYPERLINK https:/www.MedChemE/k-ras-ligand-li

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