血管支架論文血管支架物理力學(xué)性能實(shí)驗(yàn)研究

1、血管支架論文：血管支架物理力學(xué)性能實(shí)驗(yàn)研究【中文摘要】近年來隨著血管支架用量的逐年增加,人們?cè)絹碓疥P(guān)注其在使用過程中的安全性和有效性問題,物理力學(xué)性能是保證使用有效性以及決定臨床使用效果的關(guān)鍵因素。但目前物理力學(xué)性能指標(biāo)的檢測(cè)以各個(gè)廠家的自定標(biāo)準(zhǔn)為主,實(shí)驗(yàn)方法的差異造成了產(chǎn)品間對(duì)比的困難性,因此在統(tǒng)一實(shí)驗(yàn)方法的基礎(chǔ)上對(duì)支架的性能進(jìn)行研究具有重要的理論價(jià)值。本文以血管支架的物理力學(xué)性能為研究對(duì)象,在相同實(shí)驗(yàn)條件下對(duì)血管支架進(jìn)行實(shí)驗(yàn)研究和性能比對(duì)研究：通過對(duì)血管支架的物理力學(xué)性能指標(biāo)進(jìn)行綜合分析,選擇支架的徑向力學(xué)性能和耐疲勞性能進(jìn)行研究,分析得出關(guān)鍵性的影響因素,為后續(xù)實(shí)驗(yàn)研究建立理論基礎(chǔ)。平行

2、選擇了相同適應(yīng)癥、相同公稱內(nèi)徑的球囊擴(kuò)張式支架,以及不同用途的自膨式支架作為研究對(duì)象,進(jìn)行了徑向力學(xué)性能的實(shí)驗(yàn)研究,研究結(jié)果表明：統(tǒng)一的實(shí)驗(yàn)方法有利于血管支架間性能的比較,但對(duì)血管支架優(yōu)劣的比較,則應(yīng)考慮各個(gè)因素的綜合影響；實(shí)際血管支架間的個(gè)體差異性和復(fù)雜性,決定了對(duì)支架成品進(jìn)行實(shí)驗(yàn)研究的必要性并應(yīng)建立相應(yīng)的評(píng)價(jià)體系。對(duì)血管支架耐疲勞性能實(shí)驗(yàn)的關(guān)鍵參數(shù)進(jìn)行了測(cè)試分析,并對(duì)疲勞實(shí)驗(yàn)后血管支架的徑向力學(xué)性能進(jìn)行實(shí)驗(yàn)研究,簡(jiǎn)化了疲勞實(shí)驗(yàn)過程中參數(shù)測(cè)試的步驟,結(jié)論表明疲勞實(shí)驗(yàn)顯著降低了血管支架的徑向力學(xué)性能,提出應(yīng)建立疲勞實(shí)驗(yàn)后的評(píng)價(jià)體系。本課題的研究將相同產(chǎn)品、相同實(shí)驗(yàn)條件的觀念引入目前的檢測(cè)理念,

3、彌補(bǔ)了目前實(shí)際產(chǎn)品檢測(cè)數(shù)據(jù)的空白,并首次在相同冠脈支架間進(jìn)行了橫向?qū)Ρ?提出了血管支架評(píng)價(jià)方法的解決方案,為建立血管支架產(chǎn)品檢測(cè)評(píng)價(jià)體系奠定了基礎(chǔ)?！居⑽恼緿ue to the increasing of the use of vascular stent, more and more people make more attention to its safety and effection, the physical and mechanics performance of the stent is the critical factors to decide the clinical

4、 effection, but the requirment of the physical and mechanics performance is mainly focus on the standard which is compiled by manufacture themselves, its difficult to compare the products performance without the unified inspection method, so there will have the important theorys value to make the re

5、search to study the vascular stent performance on the basis of unified testing method.The study choose the physical and mechanics performance of vascular stent as object of study to build the experiment reasearch and performance comparison based on the same testing conditions.First I analysis the ma

6、in physical and mechanics performance of vascular stent, choose the performance of radial force and fatigue resistence as the crucial target to research, have the factor which influent them, and build the theory basis to the following study. Then I choose the balloon expandable stent with the same n

7、ominal diameter and same indication, the self-expandable stent with different application to do the radial force performance study, the result indicate that the same testing method is benefit to compare the performance of vascular stent, but when you want to know which stent product is best, you mus

8、t consider all the factors that influence the stents function. Due to the individual different and complexity, its necessary to do the experiment on the stent product and build an evaluation system used to compare the stent. I make a experiment study to the crucial data of the fatigue resistence per

9、formance, simplifing the steps of data testing, and study the stents radial force performance after the fatigue testing, the result indicate that the fatigue testing reduce the radial force performance of the stent, it need to build the evaluation system after the fatigue testing.The study bring the idea of same product and same condition to the inspection theory, remedy a blank of real product inspection data, compare the stent performance for the first time, give the solution idea to evaluate the stent, make a theory basis to build the