布魯菌屬生物教學(xué)課件

1、department of microbiology, harbin medical university第24章布魯菌屬 微生物學(xué)教研室 鐘照華教授 商慶龍講師 department of microbiology, harbin medical universityn掌握內(nèi)容u掌握主要生物學(xué)性狀（抗原構(gòu)造與分型） department of microbiology, harbin medical university？ department of microbiology, harbin medical university布魯菌屬 brucellan引起人類、家畜和其它動(dòng)物布魯菌病n分

2、6個(gè)生物種department of microbiology, harbin medical university生物學(xué)性狀n革蘭陰性小桿菌n無鞭毛，不形成芽胞，光滑型菌株有微莢膜department of microbiology, harbin medical university n專性需氧n生長(zhǎng)緩慢n分解葡萄糖，產(chǎn)生少量酸n過氧化氫酶陽性，氧化酶陽性n產(chǎn)生h2sdepartment of microbiology, harbin medical university流行環(huán)節(jié)n易感者u人和動(dòng)物department of microbiology, harbin medical univ

3、ersitydepartment of microbiology, harbin medical university分泌物、乳品分泌物、乳品消化道、呼吸道粘消化道、呼吸道粘膜、皮膚及眼結(jié)膜膜、皮膚及眼結(jié)膜人人菌血癥菌血癥16w潛伏期潛伏期（70）發(fā)熱、出汗、發(fā)熱、出汗、關(guān)節(jié)痛和全關(guān)節(jié)痛和全身乏力身乏力內(nèi)毒素內(nèi)毒素進(jìn)入肝、脾、骨髓進(jìn)入肝、脾、骨髓（發(fā)熱消退）（發(fā)熱消退）繁殖入血繁殖入血菌血癥菌血癥（體溫再次上升）（體溫再次上升）波浪熱波浪熱department of microbiology, harbin medical university致病性n致病物質(zhì)department of mic

4、robiology, harbin medical university所致疾病n母畜流產(chǎn)department of microbiology, harbin medical universityu波浪熱 undulant fever體溫逐日上升，達(dá)到高熱程度后，持續(xù)若干時(shí)日，再逐漸降至正常，經(jīng)過數(shù)日后又重發(fā)作，如此互相交替 department of microbiology, harbin medical university微生物學(xué)檢查法n分離培養(yǎng)與鑒定n血清學(xué)試驗(yàn)department of microbiology, harbin medical university防治原則n嚴(yán)格管理

5、病畜，消滅動(dòng)物感染n預(yù)防接種 department of microbiology, harbin medical universitybiologynsmall gram-negative rods without capsulenobligatory aerobicngrows slowly in enriched culture media with 10% co2nh2s + department of microbiology, harbin medical universitypathogens human pathogen animal reservoirsdepartment

6、of microbiology, harbin medical universitytransmissionnenter human body by department of microbiology, harbin medical universitypathogenesis localized in the reticuloendothelial system (lymph nodes, liver, spleen, and bone marrow)ncause granulomatosis, abscess, and caseationnno exotoxin is produced,

7、 so endotoxin is the major virulent factor department of microbiology, harbin medical universitydisease: brucellosisnanimaluabortiondepartment of microbiology, harbin medical universitydiagnosisnisolationusample: blood, bone marrowdepartment of microbiology, harbin medical universityprevention & therapynpasteurization of milknimmunizationuan