Hypoglycemic-agent-3-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEHypoglycemicagent3Cat.No.:HY-170692分?式:C??H??NO?分?量:529.75作?靶點:Akt;PI3K;NF-κB作?通路:PI3K/Akt/mTOR;NF-κB儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Hypoglycemicagent3(CompoundH26)，科羅索酸衍?物，具有降脂和顯著的降?糖作?，可作為?種降?糖劑。Hypoglycemicagent3通過靶向MCCC1來抑制胰島素抵抗，可以?于?型糖尿病的研究[1]。體外研究Hypoglycemicagent3(CompoundH26)(40-320μM;24h)showsnosignificantcytotoxicityinHepG2cells[1].Hypoglycemicagent3(20-40μM)suppressesinsulinresistanceprimarilybyincreasingMCCC1inHepG2cells[1].Hypoglycemicagent3(20μM;1h)significantlyinhibitstheincreaseinglucoseproductioninducedbyglucosamine(18mM;18h)(HY-B1125)inHepG2cells[1].Hypoglycemicagent3(2.5-20μM;1h)canactivatePI3K-AKTandinhibitNF-κBsignalingpathwayinHepG2cells[1].WesternBlotAnalysis[1]CellLine:HepG2Concentration:2.5,10,20μMIncubationTime:1hResult:EhancedthephosphorylationlevelsofKTandGSK3β.SgnificantlyincreasedtheexpressionofIκBα,suggestingthatH26mayinhibittheactivationofNF-κB.REFERENCES[1].HuangG,etal.CorosolicacidanditsderivativestargetingMCCC1againstinsulinresistanceandtheirhypoglycemiceffectontype2diabeticmice[J].EuropeanJournalofMedicinalChemistry,2024:117184.McePdfHeight1/1MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792