Glycochenodeoxycholic-acid-sodium-salt-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEGlycochenodeoxycholicacidsodiumsalt(Standard)Cat.No.:HY-N2334ARCASNo.:16564-43-5分子式:C??H??NNaO?分子量:471.61作用靶點(diǎn):EndogenousMetabolite;EndogenousMetabolite;Apoptosis;Apoptosis;STAT;STAT;BCL6;BCL6;InterleukinRelated;InterleukinRelated;Caspase;Caspase作用通路:MetabolicEnzyme/Protease;Apoptosis;JAK/STATSignaling;StemCell/Wnt;Immunology/Inflammation儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Glycochenodeoxycholicacidsodiumsalt(Standard)是Glycochenodeoxycholicacidsodiumsalt的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Glycochenodeoxycholicacidsodiumsalt(Chenodeoxycholylglycine)是肝臟中由甘氨鵝脫氧膽酸和甘氨酸產(chǎn)生的一種相對(duì)有毒的膽鹽。Glycochenodeoxycholicacidsodiumsalt通過(guò)抑制人正常肝細(xì)胞中溶REFERENCESGonzalezB,etal.Glycochenodeoxycholicacid(GCDC)inducedhepatocyteapoptosisisassociatedwithearlymodulationofintracellularPKCactivity.MolCellBiochem.2000Apr;207(1-2):19-27.LanW,etal.GlycochenodeoxycholicacidsodiumsaltimpairstranscriptionfactorE3-dependentautophagy-lysosomemachinerybydisruptingreactiveoxygenspecieshomeostasisinL02cells[J].ToxicolLett.2020Oct1;331:11-21.WangA,etal.GlycochenodeoxycholicacidsodiumsaltDoesNotIncreaseTransformingGrowthFactor-BetaExpressioninBileDuctEpithelialCellsorCollagenSynthesisinMyofibroblasts[J].JClinExpHepatol.2017Dec;7(4):316-320.ShiC,etal.GlycochenodeoxycholicacidsodiumsaltinducesstemnessandchemoresistanceviatheSTAT3signalingpathwayinhepatocellularcarcinomacells[J].Aging(AlbanyNY).2020Aug3;12(15):15546-15555.GonzalezB,etal.Glycochenodeoxycholicacid(GCDC)inducedhepatocyteapoptosisisassociatedwithearlymodulationofintracellularPKCactivity.MolCellBiochem.2000Apr;207(1-2):19-27.LanW,etal.GlycochenodeoxycholicacidsodiumsaltimpairstranscriptionfactorE3-dependentautophagy-lysosomemachinerybydisruptingreactiveoxygenspecieshomeostasisinL02cells[J].ToxicolLett.2020Oct1;331:11-21.WangA,etal.GlycochenodeoxycholicacidsodiumsaltDoesNotIncreaseTransformingGrowthFactor-BetaExpressioninBileDuctEpithelialCellsorCollagenSynthesisinMyofibroblasts[J].JClinExpHepatol.2017Dec;7(4):316-320.1/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemEShiC,etal.GlycochenodeoxycholicacidsodiumsaltinducesstemnessandchemoresistanceviatheSTAT3signalingpathwayinhepatocellularcarcinomacells[J].Aging(AlbanyNY).2020Aug3;12(15):15546-15555.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplication