Paroxetine-d4-BRL29060-d-sub-4-sub-生命科學試劑-MCE-2193

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEParoxetine-d4Cat.No.:HY-122272SCASNo.:923932-45-0Synonyms:BRL29060-d4分?式:C??H??D?FNO?分?量:333.39作?靶點:Isotope-LabeledCompounds;SerotoninTransporter;AdrenergicReceptor;Apoptosis;P2XReceptor作?通路:Others;NeuronalSignaling;GPCR/GProtein;Apoptosis;MembraneTransporter/IonChannel儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Paroxetine-d4(BRL29060-d4)氘代標記的Paroxetine。Paroxetine?種可?服的的抑制劑，選擇性?素再攝取抑制劑(SSRI)，也?種?常弱的去甲腎上腺素(NE)攝取抑制劑，可誘導細胞凋亡并具有抗腫瘤活性。Paroxetine具有抗抑郁、抗焦慮、鎮(zhèn)痛作?，并可改強迫癥、恐慌癥、創(chuàng)傷后應激障礙、經(jīng)前焦慮癥和慢性頭痛[1][2][3][4]。REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019Feb;53(2):211-216.[2].Young-WooCho,etal.ParoxetineInducesApoptosisofHumanBreastCancerMCF-7CellsthroughCa2+-andp38MAPKinase-DependentROSGeneration.Cancers(Basel).2019Jan9;11(1):64.[3].MBourin,etal.Paroxetine:areview.CNSDrugRev.Spring2001;7(1):25-47[4].MalekZarei,etal.Paroxetineattenuatesthedevelopmentandexistingpaininaratmodelofneurophaticpain.IranBiomedJ.2014;18(2):94-100.[5].SLightowler,etal.Anxiolytic-likeeffectofparoxetineinaratsocialinteractiontest.PharmacolBiochemBehav.1994Oct;49(2):281-5.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: