Ifenprodil-RC-61-91-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEIfenprodilCat.No.:HY-12882CASNo.:23210-56-2Synonyms:RC61-91;NP-120分?式:C??H??NO?分?量:325.44作?靶點(diǎn):iGluR作?通路:MembraneTransporter/IonChannel;NeuronalSignaling儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Ifenprodil(RC61-91)?種?競爭性NMDA受體拮抗劑，具有抗興奮性毒性的活性。Ifenprodil顯著改了急性蛛?膜下腔出?后??的長期感覺運(yùn)動(dòng)和空間學(xué)習(xí)缺陷。Ifenprodil能減少實(shí)驗(yàn)性蛛?膜下腔出?引起的基底?層和海馬CA1區(qū)的神經(jīng)細(xì)胞死亡。Ifenprodil可減輕底?質(zhì)細(xì)胞和線粒體的Ca2+超載,以及?腦屏障損傷和早期腦損傷的腦?腫。Ifenprodil降低了在?濃度?氨酸條件下，初級?層神經(jīng)元的細(xì)胞內(nèi)Ca2+增加和細(xì)胞凋亡。Ifenprodil還減?了在?腦微?管內(nèi)?細(xì)胞中，由?濃度?氨酸引起的內(nèi)?通透性增加。Ifenprodil還抑制GIRK通道，并與α1腎上腺素能、5-HT和σ受體相互作?。戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?Chemosphere.2019Aug;229:618-630.?AntimicrobAgentsChemother.2024Oct3:e0103524.?EurJPharmacol.2024Jul25:176860.?EurJPharmacol.2023Nov6:176174.?ExpBrainRes.2023Oct16.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].IfenprodilImprovesLong-TermNeurologicDeficitsThroughAntagonizingGlutamate-InducedExcitotoxicityAfterExperimentalSubarachnoidHemorrhage1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax/p>