Oxiconazole-nitrate-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEOxiconazolenitrate(Standard)Cat.No.:HY-B1324RCASNo.:64211-46-7分子式:C??H??Cl?N?O?分子量:492.14作用靶點(diǎn):Fungal;CytochromeP450;Antibiotic作用通路:Anti-infection;MetabolicEnzyme/Protease儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Oxiconazolenitrate(Standard)是Oxiconazolenitrate的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Oxiconazole(Ro13-8996)nitrate是一種廣譜抗真菌劑，能抑制念珠菌(Candida)、曲霉屬真菌(Aspergillus)和毛癬菌屬真菌(Trichophyton)的生長(zhǎng)。Oxiconazolenitrate也是一種高效的CYP3A4反式激活劑，可與利福平(Rifampicin;HY-B0272)競(jìng)爭(zhēng)性拮抗。Oxiconazolenitrate通過(guò)過(guò)氧化物酶2(PRDX2)介導(dǎo)的細(xì)胞自噬(autophagy)停滯來(lái)發(fā)揮抑制結(jié)直腸癌的作用。IC50&Target MIC90:0.25μg/mL(T.tonsurans),0.5μg/mL(T.rubrum)[1]REFERENCESRosselloA,etal.Synthesis,antifungalactivity,andmolecularmodelingstudiesofnewinvertedoximeethersofoxiconazole.JMedChem.2002Oct24;45(22):4903-12.SvecovaL,etal.Azoleantimycoticsdifferentiallyaffectrifampicin-inducedpregnaneXreceptor-mediatedCYP3A4geneexpression.DrugMetabDispos.2008Feb;36(2):339-48.ShiJ,etal.RepurposingOxiconazoleagainstColorectalCancerviaPRDX2-mediatedAutophagyArrest.IntJBiolSci.2022May21;18(9):3747-3761.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021-5