姜黃和乙醇對(duì)染苯小鼠CYP2E1及血液學(xué)毒性的影響的綜述報(bào)告_第1頁(yè)
姜黃和乙醇對(duì)染苯小鼠CYP2E1及血液學(xué)毒性的影響的綜述報(bào)告_第2頁(yè)
姜黃和乙醇對(duì)染苯小鼠CYP2E1及血液學(xué)毒性的影響的綜述報(bào)告_第3頁(yè)
全文預(yù)覽已結(jié)束

下載本文檔

版權(quán)說(shuō)明:本文檔由用戶提供并上傳,收益歸屬內(nèi)容提供方,若內(nèi)容存在侵權(quán),請(qǐng)進(jìn)行舉報(bào)或認(rèn)領(lǐng)

文檔簡(jiǎn)介

姜黃和乙醇對(duì)染苯小鼠CYP2E1及血液學(xué)毒性的影響的綜述報(bào)告摘要本文綜述了姜黃和乙醇對(duì)染苯小鼠CYP2E1及血液學(xué)毒性的影響。結(jié)果表明,姜黃和乙醇均可顯著增加染苯小鼠肝臟中CYP2E1表達(dá)水平,且在聯(lián)合作用下更為顯著。同時(shí),姜黃和乙醇對(duì)染苯小鼠造成了不同程度的血液學(xué)毒性影響,包括白細(xì)胞計(jì)數(shù)、紅細(xì)胞計(jì)數(shù)、血紅蛋白含量、血小板計(jì)數(shù)等。然而,姜黃和乙醇在一定程度上可以減輕染苯引起的某些血液學(xué)毒性表現(xiàn),這可能與它們的抗氧化和抗發(fā)炎作用有關(guān)。因此,在染苯中毒治療中可能具有一定的應(yīng)用前景。關(guān)鍵詞:姜黃、乙醇、染苯、CYP2E1、血液學(xué)毒性IntroductionBenzene(C6H6)isawell-knowntoxicenvironmentalpollutantthatiswidelyusedinindustryanddailylife.Chronicexposuretobenzenecancauseaseriesofhematologicaltoxicities,includingaplasticanemia,pancytopenia,andmyelodysplasticsyndrome,whichhasbecomeaglobalhealthconcern(1).CYP2E1,amajorcytochromeP450enzymeinvolvedinthemetabolismofbenzene,isresponsibleforthegenerationoftoxicbenzenemetabolitessuchas1,2-dihydroxybenzeneand1,4-benzoquinone(2).OverexpressionofCYP2E1canexacerbatebenzene-inducedhematotoxicitybyincreasingtheproductionoftoxicmetabolites,whileinhibitionofCYP2E1activitycanreducebenzenetoxicity(3).Curcumin,themainactiveingredientinturmeric,hasbeenwidelyinvestigatedforitsanti-inflammatory,antioxidant,andanti-canceractivities(4).Studiesindicatethatcurcumincanprotectagainstbenzene-inducedtoxicitybyinhibitingCYP2E1-mediatedbenzenemetabolismandscavengingfreeradicals(5).Ethanol,anothercommonlyconsumedsubstance,hasbeenreportedtoaffectbenzenemetabolismandtoxicity(6).However,theeffectsofcurcuminandethanolonCYP2E1activityandhematologicaltoxicityinbenzene-exposedanimalsremaincontroversial.Therefore,thisreviewaimstosummarizetheeffectsofcurcuminandethanolonCYP2E1expressionandhematologicaltoxicityinbenzene-exposedmice.EffectsofcurcuminonCYP2E1expressionStudieshavedemonstratedthatcurcumincaninhibitCYP2E1expressionandactivityinvarioustissues,includingliver,kidney,andlung(7).Inabenzene-exposedmousemodel,curcuminsignificantlyreducedthelevelsofCYP2E1mRNAandproteinintheliver,aswellasthelevelsof1,2-dihydroxybenzeneand1,4-benzoquinoneintheblood(8).Inaddition,curcumininhibitedbenzene-inducedoxidativestressbyenhancingantioxidantenzymeactivities,suchassuperoxidedismutaseandglutathioneperoxidase(9).Thesefindingssuggestthatcurcumincanprotectagainstbenzene-inducedtoxicitybysuppressingCYP2E1expressionandreducingtheproductionoftoxicmetabolites.EffectsofethanolonCYP2E1expressionEthanolhasbeenreportedtoinduceCYP2E1expressionandactivityintheliver,whichcanexacerbatethetoxicityofvariouschemicals,includingbenzene(10).Inabenzene-exposedmousemodel,ethanolsignificantlyincreasedtheexpressionandactivityofCYP2E1intheliver,aswellasthelevelsof1,2-dihydroxybenzeneand1,4-benzoquinoneintheblood(11).Interestingly,thecombinationofcurcuminandethanolfurtherelevatedCYP2E1expressionandactivity,suggestingapotentialsynergisticeffectonbenzenemetabolism(12).Theseresultshighlighttheimportanceofavoidingethanolconsumptionduringbenzeneexposuretominimizetheriskofhematologicaltoxicity.EffectsofcurcuminandethanolonhematologicaltoxicityBenzene-inducedhematologicaltoxicityhasbeenwidelydocumentedinanimalandhumanstudies.Inthebenzene-exposedmousemodel,benzenesignificantlyreducedthelevelsofredbloodcells,hemoglobin,andplatelets,aswellasthecountsofwhitebloodcells(13).Interestingly,bothcurcuminandethanolalonecanamelioratecertainaspectsofbenzene-inducedhematologicaltoxicity.Forexample,curcuminincreasedthelevelsofredbloodcellsandhemoglobin,whilereducingthecountsofwhitebloodcells(14).Ethanol,ontheotherhand,increasedthecountsofwhitebloodcellsandplatelets,buthadnosignificanteffectonredbloodcellsorhemoglobin(15).Whencurcuminandethanolwereadministeredincombination,theeffectsonhematologicaltoxicitywerecomplexandvarieddependingonthespecificoutcomemeasures.Forexample,thecombinationsignificantlyincreasedthecountsofwhitebloodcellsandplateletscomparedtobenzeneexposurealone,buthadnosignificanteffectonredbloodcellsorhemoglobin(16).Thesefindingssuggestthatthecombinationofcurcuminandethanolmayhavedifferentialeffectsonvariousaspectsofhematologicaltoxicityinbenzene-exposedanimals.ConclusionThisreviewhighlightstheimportanceofCYP2E1inbenzenemetabolismandhematologicaltoxicity,aswellasthepotentialprotectiveeffectsofcurcuminandthedetrimentaleffectsofethanol.CurcumincaninhibitCYP2E1expressionandprotectagainstbenzene-inducedhematotoxicity,whileethanolcaninduceCYP2E1expressionandexacerbatebenzenetoxicity.Thecombinationofcurcuminandethanolmayhavecomplexanddifferentialeffectsonvariousaspectsofhematologicaltoxicity.Overall,thesefindingssuggestthatcurcuminandethanolshouldbecarefullyevaluatedandused

溫馨提示

  • 1. 本站所有資源如無(wú)特殊說(shuō)明,都需要本地電腦安裝OFFICE2007和PDF閱讀器。圖紙軟件為CAD,CAXA,PROE,UG,SolidWorks等.壓縮文件請(qǐng)下載最新的WinRAR軟件解壓。
  • 2. 本站的文檔不包含任何第三方提供的附件圖紙等,如果需要附件,請(qǐng)聯(lián)系上傳者。文件的所有權(quán)益歸上傳用戶所有。
  • 3. 本站RAR壓縮包中若帶圖紙,網(wǎng)頁(yè)內(nèi)容里面會(huì)有圖紙預(yù)覽,若沒(méi)有圖紙預(yù)覽就沒(méi)有圖紙。
  • 4. 未經(jīng)權(quán)益所有人同意不得將文件中的內(nèi)容挪作商業(yè)或盈利用途。
  • 5. 人人文庫(kù)網(wǎng)僅提供信息存儲(chǔ)空間,僅對(duì)用戶上傳內(nèi)容的表現(xiàn)方式做保護(hù)處理,對(duì)用戶上傳分享的文檔內(nèi)容本身不做任何修改或編輯,并不能對(duì)任何下載內(nèi)容負(fù)責(zé)。
  • 6. 下載文件中如有侵權(quán)或不適當(dāng)內(nèi)容,請(qǐng)與我們聯(lián)系,我們立即糾正。
  • 7. 本站不保證下載資源的準(zhǔn)確性、安全性和完整性, 同時(shí)也不承擔(dān)用戶因使用這些下載資源對(duì)自己和他人造成任何形式的傷害或損失。

評(píng)論

0/150

提交評(píng)論