Amitriptyline-hydrochloride-Standard-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAmitriptylinehydrochloride(Standard)Cat.No.:HY-B0527ARCASNo.:549-18-8分?式:C??H??ClN分?量:313.86作?靶點(diǎn):SerotoninTransporter;5-HTReceptor;HistamineReceptor;mAChR;AdrenergicReceptor;SodiumChannel;TrkReceptor作?通路:NeuronalSignaling;GPCR/GProtein;

Immunology/Inflammation;MembraneTransporter/Ion

Channel;ProteinTyrosineKinase/RTK儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:≥100mg/mL(318.61mM)H2O:≥50mg/mL(159.31mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.1861mL15.9307mL31.8613mL5mM0.6372mL3.1861mL6.3723mL10mM0.3186mL1.5931mL3.1861mLBIOLOGICALACTIVITY?物活性Amitriptyline(hydrochloride)(Standard)Amitriptyline(hydrochloride)的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Amitriptylinehydrochloride?種?素再攝取轉(zhuǎn)運(yùn)體(SERT)和去甲腎上腺素再攝取轉(zhuǎn)運(yùn)體(NET)抑制劑，對?的SERT和NET作?的Ki值分別為3.45nM和13.3nM。Amitriptylinehydrochloride還與多巴胺再攝取轉(zhuǎn)運(yùn)體(DAT)結(jié)合，其Ki為2.58μM。Amitriptylinehydrochloride也抑制腎上腺素能受體(adrenergicreceptor)、毒蕈堿受體(muscarinicreceptor)、組胺受體(histaminereceptor)、5-羥?胺受體(5-HTreceptor)。Amitriptylinehydrochloride?種具有強(qiáng)神經(jīng)營養(yǎng)活性的TrkA和TrkA受體激動劑。1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEAmitriptylinehydrochloride具有抗抑郁作?[1][2][3]。IC50&TargetTrkATrkB戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?JMedVirol.2022Nov1.?CellCommunSignal.2023May25;21(1):123.?PLoSNeglTropDis.2019Aug20;13(8):e0007681.Seemorecustomervalidationsonwww.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589