Ribavirin-GMP-Ribasphere-GMP-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemERibavirin(GMP)Cat.No.:HY-B0434GCASNo.:36791-04-5Synonyms:Ribasphere(GMP);ICN-1229(GMP)分子式:C?H??N?O?分子量:244.2作用靶點(diǎn):Antibiotic;RSV;HCV;Orthopoxvirus作用通路:Anti-infection儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Ribavirin(GMP)是GMP級(jí)別的Ribavirin(HY-B0434)。GMP級(jí)別的小分子可用做細(xì)胞療法中的輔助試劑。Ribavirin(ICN-1229)是廣譜的抗病毒劑，可抑制HCV，HIV，RSV等病毒。Ribavirin還具有抗正痘病毒(orthopoxvirus)和抗天花病毒活性。體外研究TreatmentofLPS-stimulatedmicrogliawith5,10and20μMRibavirinGMP(ICN-1229)inducesreductionofNO2levelsfor43%(p[3].RibavirinGMP(ICN-1229)isactiveagainstDENV,withanEC50of3μMinA549cells,andcombinationofCM-10-18withRibavirinGMP(ICN-1229)demonstratesaclearenhancementinthereductionofvirusreplication[4].Ribavirin(20μM,7d)inhibitshepatitisCvirus(HCV)replicationinFunctionalhepatocyte-likecellswhichdevelopedfromhiPSC[6].Ribavirin(1,10,25μg/ml,72h)attenuatesZIKV-inducedcellapoptosisinhNPCsviamodulationofapoptosis-regulatorygenesandpromotessurvivalsignalingviathePI3K/AKTpathway[7].RealTimeqPCR[7]CellLine:hNPCsConcentration:1,10,25μg/mlIncubationTime:72h1/3 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemEResult:IncreasedBCL2mRNAlevelsanddecreasedBAXmRNAlevelscomparedwithDMSOcontrol-treatedcells.WesternBlotAnalysis[7]CellLine:hNPCsConcentration:1,10,25μg/mlIncubationTime:72hResult:IncreasedphosphorylationofAKTcomparedtocontrol-treatedZIKV-infectedcells.體內(nèi)研究ALT,ASTactivitiesandbilirubinlevelsaresignificantlyloaredbyadministrationofJATincombinationwithinterferonandRibavirinGMP(ICN-1229)(p4,liversappeartoexhibitsomeliverprotectionagainstCCl4asevidentbythepresenceofnormalhepaticcords,absenceofnecrosisandlesserfattyinfiltration.GroupstreatedwithJAT,Peg-interferonandRibavirinGMP(ICN-1229)separatelyorincombinationshowsreductionintheexpressionofTGF-βandBax.Inthegrouptreatedbytriplecombinationofinterferon,RibavirinGMP(ICN-1229),andJAT,theexpressionlevelofp53ismarkedlyreduced[1].RibavirinGMP(ICN-1229)capsules(400mgofRibavirinGMP)-treatedWistarratsshowasignificantdecreaseinactivin-Aandsignificantincreaseinfollistatinattheserumandliverlevels.RibavirinGMP(ICN-1229)hasstrongantiviralactivityonlywhenRibavirinGMPiscombinedwitheitherIFN-αorPeg-IFN-α[2].RibavirinGMP(40mg/kg,p.o.)significantlyimprovestheantiviralefficacyofCM-10-18inmice.RibavirinGMP(ICN-1229)inhibitsDENVvirusinfectioninculturedcells,butitisineffectiveinreducingviremiainmonotherapy[4].客戶使用本產(chǎn)品發(fā)表的科研文獻(xiàn)BMCMed.2020Jul31;18(1):204.AntiviralRes.2023Aug21;105703.AntiviralRes.2022Jul19;205:105384.AntiviralRes.2021Jan;185:104977.AntiviralRes.2018Jun;154:51-57.Seemorecustomervalidationsonwww.MedChemEREFERENCESRobertOBaker,etal.Potentialantiviraltherapeuticsforsmallpox,monkeypoxandotherorthopoxvirusinfections.AntiviralRes.2003Jan;57(1-2):13-23.Abdel-HamidNM,etal.SynergisticEffectsofJerusalemArtichokeinCombinationwithPegylatedInterferonAlfa-2aandRibavirinAgainstHepaticFibrosisinRats.AsianPacJCancerPrev.2016;17(4):1979-85.RefaatB,etal.Theeffectsofpegylatedinterferon-αandribavirinonliverandserumconcentrationsofactivin-Aandfollistatininnormal2/3 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemEWistarrat:apreliminaryreport.BMCResNotes.2015Jun26;8:265SavicD,etal.Ribavirinshowsimmunomodulatoryeffectsonactivatedmicroglia.ImmunopharmacolImmunotoxicol.2014Dec;36(6):433-41ChangJ,etal.Combinationofα-glucosidaseinhibitorandribavirinforthetreatmentofdenguevirusinfectioninvitroandinvivo.AntiviralRes.2011Jan;89(1):26-34Sa-NgiamsuntornK,etal.ArobustmodelofnaturalhepatitisCinfectionusinghepatocyte-likecellsderivedfromhumaninducedpluripotentstemcellsasalong-termhost.VirolJ.2016Apr5;13:59.KimJA,SeongRK,KumarM,ShinOS.FavipiravirandRibavirinInhibitReplicationofAsianandAfricanStrainsofZikaVirusinDifferentCellModels.Viruses.2018Feb9;10(