ALW-II-49-7-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEALW-II-49-7Cat.No.:HY-18833CASNo.:1135219-23-6分?式:C??H??F?N?O?分?量:414.38作?靶點(diǎn):EphrinReceptor作?通路:ProteinTyrosineKinase/RTK儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(241.32mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.4132mL12.0662mL24.1324mL5mM0.4826mL2.4132mL4.8265mL10mM0.2413mL1.2066mL2.4132mL體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(6.03mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(6.03mM);Clearsolution3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.03mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性ALW-II-49-7?種選擇性的EphB2抑制劑，細(xì)胞內(nèi)的EC50為40nM。IC50&TargetEphB2[1]體外研究ALW-II-49-7(compound9)exhibitsselectivityprofileofbindingtoasetofkinasesincludingb-raf,CSF1R,DDR1,DDR2,EphA2,EphA5,EphA8,EphB1,EphB2,EphB3,Frk,Kit,Lck,p38a,p38b,PDGFRa,PDGFRb,andRaf1[1].ALW-II-49-7(0.01-10μM;1h)inhibitsEphB2tyrosinekinaseactivityinU87glioblastomacells.EphB2isaddedinmediaat2μg/mL[1].REFERENCES[1].ChoiY,etal.DiscoveryandstructuralanalysisofEphreceptortyrosinekinaseinhibitors.BioorgMedChemLett.2009Aug1;19(15):4467-70.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021