Enpp-Carbonic-anhydrase-IN-2-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEEnpp/Carbonicanhydrase-IN-2Cat.No.:HY-151917分?式:C??H??FNO?S分?量:429.5作?靶點(diǎn):Apoptosis;CarbonicAnhydrase;Phosphodiesterase(PDE)作?通路:Apoptosis;MetabolicEnzyme/Protease儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Enpp/Carbonicanhydrase-IN-2(compound1i)?種有效的Enpp和carbonicanhydrase抑制劑，對(duì)NPP1、NPP2、NPP3、CA-IX,CA-XII的IC50值分別1.13、1.07、0.74、0.33、0.68。Enpp/Carbonicanhydrase-IN-2對(duì)癌細(xì)胞具有抗增殖活性，對(duì)正常細(xì)胞具有低細(xì)胞毒性。Enpp/Carbonicanhydrase-IN-2誘導(dǎo)細(xì)胞凋亡(Apoptosis)[1]。IC50&TargetCAⅨCAXIINPP1NPP20.33μM(IC50)0.68μM(IC50)1.13μM(IC50)1.07μM(IC50)NPP30.74μM(IC50)體外研究Enpp/Carbonicanhydrase-IN-2(compound1i)(0-100μM;)inhibitssomecancercellsgrowthwithIC50sof0.58,0.58,0.63,0.42,0.20,0.72,0.41,0.76,0.94,0.28,0.49,0.59,0.83μMforK-562,COLO205,HCT-116,HCT-15,HT29,KM12,SW-620,SF-539,NCI/ADR-RES,A498,PC-3,MCF7,T-47Dcells,respectively[1].Enpp/Carbonicanhydrase-IN-2(0-2μM)showslowcytotoxicagainstnormalbreastepithelialcells(HME1)andnormalskinfibroblastcells(F180)withIC50sof>50μM[1].Enpp/Carbonicanhydrase-IN-2(0.58,1.16μM)inducesapoptosisinadose-dependentmanneratK-562cells[1].CellProliferationAssay[1]CellLine:K-562,COLO205,HCT-116,HCT-15,HT29,KM12,SW-620,SF-539,NCI/ADR-RES,A498,PC-3,MCF7,T-47Dcells1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEConcentration:0-100μMIncubationTime:Result:InhibitedthecellgrowthwithIC50sof0.58,0.58,0.63,0.42,0.20,0.72,0.41,0.76,0.94,0.28,0.49,0.59,0.83μMforK-562,COLO205,HCT-116,HCT-15,HT29,KM12,SW-620,SF-539,NCI/ADR-RES,A498,PC-3,MCF7,T-47Dcells,respectively.ApoptosisAnalysis[1]CellLine:K-562cellsConcentration:0.58,1.16μMIncubationTime:Result:Inducedapoptosisinadose-dependentmanner.REFERENCES[1].AfnanI.Shahin,etal.Designandsynthesisofnewadamantylderivativesaspromisingantiproliferativeagents.EuropeanJournalofMedicinalChemistry,2022.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly