藥物化學(xué)合成方程式

【鹽酸普魯卡因，即：對(duì)-氨基苯甲酸-β-二乙氨基乙酯鹽酸鹽】Na2Cr2O7,H2SO4HOCHCHN(CH)2C2H5ONCH2225COOCHCHNO2NCOOHONC2H523Fe,HClHNCOOCHCHNC2H5HCl,Na2S2O4,NaClHNCOOCHCHNC2H5.HCl222C2H5pH=4.2222C2H5【鹽酸氯丙嗪，即：2-氯-10-（3-二甲氨基丙基）吩噻嗪鹽酸鹽】CH=CHCHOH+(CH)NHNaOH(CH)NCHCHCHOHSOCl.NaOH2NCHCHCHCl(CH)NCHCHCHCl1、120-12550-60HCl3222232222COOHCOOHCOOHH2NClCOOHNH2NaNO2N.ClCuClNHClFe/NHCl2ClHCl22Cu/NaOH-CO2、2CHCHCHN(CH)22223NHClNCHCHCHClNaOHNCl+(CH)S32222S3、【奮乃靜，即：2-氯-10-﹛3-〔4-（β-羥乙基）哌嗪〕丙基﹜吩噻嗪】HNNH.6HO+22-300NCHCHOHBrCHCHCHCl222ClCHCHCHNNCH2CH2OHO222222NaOHCH2CH2CH2NNCH2CH2OHNHClNClCHCHOH+ClCHCHCHNNSS222【布洛芬，即：2-（4-異丁基苯基）丙酸】CHCHCH(CH3CO)2OCOCHCH32CHCH(CH)(CH)CHCHAlCl3232CHCHCH1)(CH)CHCHCCHCOOC2(CH)CHCHCHCHO2(CH)CHCHCHCOOHCHONaH+,CO2)OH-轉(zhuǎn),H位+25O2)2322-【醋氨酚，即：對(duì)乙酰氨基苯酚】NONHNHCOCHHNO/HSOFe/HClCHCOOH3243OHOHOHOH【鹽酸哌替啶，即：1-甲基-4-苯基哌啶-4-羧酸乙酯鹽酸鹽】CHCHClCHCHCNHSOCHCHOHCHCHH3CNHCNH3CNH3CNCHCHCl65HOCOOHCOOCHNaNH2/3CN22225HCl/CHOHC6H525H3CN.HClCOOCH25【肌安松，即：內(nèi)消旋3,4-雙(對(duì)二甲氨基苯基)己烷雙碘甲烷鹽】CHCONHNaClO/NaOHCHNHNaNO/HClHBr(50%)CHBrFe/HOCH2CHOH2CH2Hofmann2C2H5CHCHC2H5CHCH252525HNO/(AC)OO2NCHCHNOFe/HClHNCHCHNH2CHCOOH2CH2CHCHCH325252525CHI/CaCO+CHCH+.-33N(CH)CHOH(CH3)3N332I3CHCH2525【鹽酸多巴胺，即：3，4-二羥基苯乙胺鹽酸鹽】CHOCHOCHNOCHOCH=CHNOZn-HgCHOCHCHNH3222.HCl33232HClHOHOHOHCl(加壓)HOCHCHNH222.HClHO【美西律，即：1-（2，6-二甲基苯氧基）-2-氨基丙烷鹽酸鹽】CH3OCHCHONKCH3OOCHCHCHSOClOH23OCHCHOHOCHCHClNaOH22

NaI/DMF

OCH2CHNCHCHCH3CH3CH33

CH3CH3O1)NHNHHCH32O22OCHCHNH.HCl2)HCl/C2HOH225CHCH33【溴化新斯的明，即：溴化[3-（N，N-二甲氨基甲酰氧基）苯基]三甲基銨】N(CH)+.Br-N(CH)N(CH)2N(CH)22333COCl3HN(CH)32CHBr23OHOCOClOCON(CH)2OCON(CH)23【氯貝丁酯，即：α-對(duì)氯苯氧異丁酸乙酯】OHClOHCHNaOH3ClOCCClCHCOCHCHClCHCCHNaOH333+333CCl3CH3CHCHOHCHNaOHCl3Cl3OCCOONa25OCCOOCHHSO/25CH24CH33【異煙肼，即：4-吡啶甲酰肼】CH3V2O5/H2O/OCOOHNH2NH2CONHNH22.H2O0120-130C0N270CNN【磺胺，即：對(duì)-氨基苯磺酰胺】HOSOClNHOHNaOHCHCONHCHCONHSOClCHCONHSONHH2NS=NH045C3332ASCASNOONaH+HNSONH222【鹽酸普萘洛爾，即：1-異丙氨基-3-（1-萘氧基）-2-丙醇鹽酸鹽】OKOOCHCHCHOCHCHCHNHCH(CH)HNCH(CH)222ClCH2CHCH2O23OHOCHCHCHNHCH(CH).HCl2232HClOH【度米芬，即：N-十二烷基-N，N-二甲基（2-苯氧乙基）溴化銨】CHOHOCHCHBrOCHCHN(CH)CHBr.-2+NH(CH)OCHCHHOCHCHBr2NCHBr322122522CH3【甲苯磺丁尿，即：1-正丁基-3-對(duì)甲苯磺酰尿】HOSOClNHOHNHCONH/NaOH/CHClHC2HCSOCl4HCSONHH3CSONHCONH22332322110-115CCHNH,1/2HSOSONHCONHCHC3249【環(huán)磷酰胺，即：N，N-雙-（β-氯乙基）-N`-（3-羥丙基）磷酰二胺丙酯】HOCHCHPOClClOHClCHCHNHCHCHCHOHClCHCHNHOCHCHNHNPONPCHNClCHCH22(CH)N/ClCHCHClClCHCH5522Cl2O532222HOClCHCHOHN.HO222NPCHCOCHClCHCHO23322【氟尿嘧啶，即：5-氟尿嘧啶】KFHCOOCHClCHCOOCHFCHCOOCH25[OHC-CHCOOC]CHCONHCHONa25225225F323OCHOHOHCHONa3FHClFN3NaOCH=CCOOCNH=C-NHNF252H2OCHOH/CHONHON3【OHNaNO/HClO】CHNH222OHOHHNO+HOOH2OH2CHNH-NCH-