Antifungal-agent-38-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAntifungalagent38Cat.No.:HY-151284分?式:C?H??N?S?分?量:200.32作?靶點(diǎn):Bacterial;Fungal作?通路:Anti-infection儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Antifungalagent38?種環(huán)?硫化物，具有抗真和抗細(xì)活性。Antifungalagent38能誘導(dǎo)絲收縮，破壞質(zhì)膜的完整性，造成細(xì)胞內(nèi)容物的破壞和泄漏。體外研究Antifungalagent38(50μg/mL)showsanti-fungalactivityagainst10pathogenicfungiwithinhibitionratesof56.57%(R.solani),100%(S.sclerotiorum),55.09%(B.cinerea),71.23%(F.graminearum),37.32%(M.oryzae),50.87%(P.capsici),100%(A.flavus),59.75%(P.expansum),100%(M.fructicola),65.78%(R.stolonifer),respectively[1].Antifungalagent38(5μg/mL)damagesplasmamembraneintegrityofM.fructicola[1].Antifungalagent38(100μg/mL)displaysexcellentanti-bacterialactivityagainstX.oryzaeaccc11602,X.axonpodis[1].Antifungalagent38inhibitsfungusgrowthwithEC50sof17.09μg/mL(R.solani),6.34μg/mL(S.sclerotiorum),25.24μg/mL(F.graminearum),>10μg/mL(A.flavus),10.42μg/mL(M.fructicola),45.71μg/mL(B.cinerea),respectively[1].CellViabilityAssay[1]CellLine:M.fructicolaConcentration:10,25,50μg/mLIncubationTime:2,4,6daysResult:InhibitedM.fructicolagrowth.體內(nèi)研究Antifungalagent38(compoundS8)(200μg/mL)displaysequivalentcurativeandhigherprotectiveeffectsas1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEthepositivedrugThiophanate-Methyl(HY-B0842)invivo[1].Antifungalagent38(50,100,200μg/mL,30mL;sprinkling)appliesonpearsandinhibitsM.fructicolagrowthinvivo[1].REFERENCES[1].WangJR,etal.Allicin-InspiredHeterocyclicDisulfidesasNovelAntimicrobialAgents.JAgricFoodChem.2022Sep6.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37