SHMT-IN-2-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESHMT-IN-2Cat.No.:HY-129226CASNo.:2102681-49-0分?式:C??H??F?N?O分?量:431.45作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(231.78mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.3178mL11.5888mL23.1777mL5mM0.4636mL2.3178mL4.6355mL10mM0.2318mL1.1589mL2.3178mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性SHMT-IN-2?種特異性?SHMT1/2抑制劑，對(duì)SHMT1和SHMT2的IC50值分別為13nM和66nM。SHMT-IN-2可以抑制許多?類癌細(xì)胞的?長(zhǎng)，對(duì)B細(xì)胞淋巴瘤有敏感性。IC50&TargetIC50:2800nM(SHMT1);IC50:36nM(SHMT2)[1]體外研究SHMT-IN-2(compound2)caninhibitcellgrowthwithcellularIC50valuesof2800nMand36nMforSHMT11/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEandSHMT2,respectively[1].SHMT-IN-2(30μM)showsthegrowthsensitivitywiththemedianIC50was4μMtoapanelofnearly300humancancercelllines(withIC50valuesof1.72μMand1.73μMforCCRF-CEMandHT,respectively),celllinesofB-celllymphomaoriginwereenrichedinthemoresensitivehalfofcells[1].REFERENCES[1].regorySDucker,etal.HumanSHMTinhibitorsrevealdefectiveglycineimportasatargetablemetabolicvulnerabilityofdiffuselargeB-celllymphoma.ProcNatlAcadSciUSA.2017Oct24;114(43):11404-11409.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955