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Primaryintracranialtumor:
Glioma膠質(zhì)瘤（40%）Meningioma腦膜瘤（15%）Acousticneurinoma聽神經(jīng)瘤（8%）Metastatictumors:lung,breast
§6Tumors分類發(fā)病率children:glioma,medulloblastoma
髓母細(xì)胞瘤醫(yī)學(xué)課件園Primaryintracranialtumor:§61Size,location>natureLocaleffectGeneraleffect特點(diǎn)影響B(tài)iologic~histologicmalignancyInvasionMetastasistumor醫(yī)學(xué)課件園Size,location>nature特點(diǎn)影響2Differentiation分化ClinicalprogressionGeneticchangesI.Astrocytoma星形細(xì)胞瘤AstrocytomaAnaplasticastrocytoma間變性-Glioblastomamultiforme多形性膠質(zhì)母細(xì)胞瘤醫(yī)學(xué)課件園I.AstrocytomaAstrocytoma醫(yī)學(xué)課件3atypia,mitoticrate,capillary,endothelialcells,necrosis,hemorrhageAstrocytomaAnaplasticastrocytomaGlioblastomamultiformepoorlydefinedgray-whitesolidmultiform多形性:cyst,necrosis,hemorrhageAstrocytona病變醫(yī)學(xué)課件園atypia,mitoticrate,Astrocyto4P53
mutation/lossofchr.17pLossofchr.22qRb
mutation/lossofchr.13qP16deletion/lossofchr.3pLossofchr.19qLossofch.10EGFRgeneamplificationGeneticchangesinastrocytomaNormalastrocyteAstrocytomaAnaplasticastrocytomaGlioblaxtomamultiforme醫(yī)學(xué)課件園P53mutation/lossofchr.175astrocytoma醫(yī)學(xué)課件園astrocytoma醫(yī)學(xué)課件園6醫(yī)學(xué)課件園醫(yī)學(xué)課件園7Astrocytoma醫(yī)學(xué)課件園Astrocytoma醫(yī)學(xué)課件園www.yxkjy.co8Glioblatonamultiforme醫(yī)學(xué)課件園Glioblatonamultiforme醫(yī)學(xué)課件園ww9Giantcellsinglioblastomamultiforme醫(yī)學(xué)課件園Giantcellsinglioblastomamu10Giantcellsinglioblastomamultiforme醫(yī)學(xué)課件園Giantcellsinglioblastomamu11Giantcellsinglioblastomamultiforme,IHGFAP醫(yī)學(xué)課件園Giantcellsinglioblastomamu12Pseudopalisading(glioblastomamultiforme)醫(yī)學(xué)課件園Pseudopalisading(glioblastoma13Endothelialcellproliferationglioblastomamultiforme醫(yī)學(xué)課件園Endothelialcellproliferation14<20yCerebellumPrimitiveundifferentiatedcellsmalltumorcells,scantycytoplasmrosette菊形團(tuán)SeedingthroughCSFHighlymalignantII.Medulloblastoma
髓母細(xì)胞瘤醫(yī)學(xué)課件園<20yII.Medulloblastoma醫(yī)學(xué)課件15Medulloblastoma醫(yī)學(xué)課件園Medulloblastoma醫(yī)學(xué)課件園www.yxkj16醫(yī)學(xué)課件園醫(yī)學(xué)課件園17Seedingofmedulloblastoma醫(yī)學(xué)課件園Seedingofmedulloblastoma醫(yī)學(xué)課件18
From:arachnoidcell蛛網(wǎng)膜細(xì)胞
部位:~arachnoidgranulationdura硬腦膜
大體：solid,gritty砂粒樣
光鏡：whorl-likepatternpsammoma砂粒體Malignant:rareIII.Meningioma腦膜瘤醫(yī)學(xué)課件園III.Meningioma腦膜瘤醫(yī)學(xué)課件園www19meningioma醫(yī)學(xué)課件園meningioma醫(yī)學(xué)課件園20Hereisanotherbenignmeningiomabeneaththedura.Theseneoplasmsareslowgrowing,butmayreachalargesizebeforesymptomsleadtodetection.醫(yī)學(xué)課件園Hereisanotherbenignmeningi21Meningiomaofsphenoidwing醫(yī)學(xué)課件園Meningiomaofsphenoidwing醫(yī)學(xué)課22醫(yī)學(xué)課件園醫(yī)學(xué)課件園23醫(yī)學(xué)課件園醫(yī)學(xué)課件園24醫(yī)學(xué)課件園醫(yī)學(xué)課件園25From:Schwanncell大體:encapsulated,solitary~nerves,spinalroots光鏡:Spindletumorcells,
排列成束狀，網(wǎng)狀BenignIV.Neurilemmoma神經(jīng)鞘瘤Schwannoma醫(yī)學(xué)課件園From:SchwanncellIV.Neuril26Acousticschwannoma醫(yī)學(xué)課件園Acousticschwannoma醫(yī)學(xué)課件園www.y27Schwannomaofaspinalroot醫(yī)學(xué)課件園Schwannomaofaspinalroot醫(yī)學(xué)28Acousticschwannoma醫(yī)學(xué)課件園Acousticschwannoma醫(yī)學(xué)課件園www.y29Gemistocytixastrocytoma醫(yī)學(xué)課件園Gemistocytixastrocytoma醫(yī)學(xué)課件園30Gemistocytixastrocytoma醫(yī)學(xué)課件園Gemistocytixastrocytoma醫(yī)學(xué)課件園31Schwannoma醫(yī)學(xué)課件園Schwannoma醫(yī)學(xué)課件園32醫(yī)學(xué)課件園醫(yī)學(xué)課件園33醫(yī)學(xué)課件園醫(yī)學(xué)課件園34InflammationTumorTrauma…...Edema
Hydrocephalus
IIPherniation醫(yī)學(xué)課件園EdemaHydrocephalusIIP醫(yī)學(xué)35Primaryintracranialtumor:
Glioma膠質(zhì)瘤（40%）Meningioma腦膜瘤（15%）Acousticneurinoma聽神經(jīng)瘤（8%）Metastatictumors:lung,breast
§6Tumors分類發(fā)病率children:glioma,medulloblastoma
髓母細(xì)胞瘤醫(yī)學(xué)課件園Primaryintracranialtumor:§636Size,location>natureLocaleffectGeneraleffect特點(diǎn)影響B(tài)iologic~histologicmalignancyInvasionMetastasistumor醫(yī)學(xué)課件園Size,location>nature特點(diǎn)影響37Differentiation分化ClinicalprogressionGeneticchangesI.Astrocytoma星形細(xì)胞瘤AstrocytomaAnaplasticastrocytoma間變性-Glioblastomamultiforme多形性膠質(zhì)母細(xì)胞瘤醫(yī)學(xué)課件園I.AstrocytomaAstrocytoma醫(yī)學(xué)課件38atypia,mitoticrate,capillary,endothelialcells,necrosis,hemorrhageAstrocytomaAnaplasticastrocytomaGlioblastomamultiformepoorlydefinedgray-whitesolidmultiform多形性:cyst,necrosis,hemorrhageAstrocytona病變醫(yī)學(xué)課件園atypia,mitoticrate,Astrocyto39P53
mutation/lossofchr.17pLossofchr.22qRb
mutation/lossofchr.13qP16deletion/lossofchr.3pLossofchr.19qLossofch.10EGFRgeneamplificationGeneticchangesinastrocytomaNormalastrocyteAstrocytomaAnaplasticastrocytomaGlioblaxtomamultiforme醫(yī)學(xué)課件園P53mutation/lossofchr.1740astrocytoma醫(yī)學(xué)課件園astrocytoma醫(yī)學(xué)課件園41醫(yī)學(xué)課件園醫(yī)學(xué)課件園42Astrocytoma醫(yī)學(xué)課件園Astrocytoma醫(yī)學(xué)課件園www.yxkjy.co43Glioblatonamultiforme醫(yī)學(xué)課件園Glioblatonamultiforme醫(yī)學(xué)課件園ww44Giantcellsinglioblastomamultiforme醫(yī)學(xué)課件園Giantcellsinglioblastomamu45Giantcellsinglioblastomamultiforme醫(yī)學(xué)課件園Giantcellsinglioblastomamu46Giantcellsinglioblastomamultiforme,IHGFAP醫(yī)學(xué)課件園Giantcellsinglioblastomamu47Pseudopalisading(glioblastomamultiforme)醫(yī)學(xué)課件園Pseudopalisading(glioblastoma48Endothelialcellproliferationglioblastomamultiforme醫(yī)學(xué)課件園Endothelialcellproliferation49<20yCerebellumPrimitiveundifferentiatedcellsmalltumorcells,scantycytoplasmrosette菊形團(tuán)SeedingthroughCSFHighlymalignantII.Medulloblastoma
髓母細(xì)胞瘤醫(yī)學(xué)課件園<20yII.Medulloblastoma醫(yī)學(xué)課件50Medulloblastoma醫(yī)學(xué)課件園Medulloblastoma醫(yī)學(xué)課件園www.yxkj51醫(yī)學(xué)課件園醫(yī)學(xué)課件園52Seedingofmedulloblastoma醫(yī)學(xué)課件園Seedingofmedulloblastoma醫(yī)學(xué)課件53
From:arachnoidcell蛛網(wǎng)膜細(xì)胞
部位:~arachnoidgranulationdura硬腦膜
大體：solid,gritty砂粒樣
光鏡：whorl-likepatternpsammoma砂粒體Malignant:rareIII.Meningioma腦膜瘤醫(yī)學(xué)課件園III.Meningioma腦膜瘤醫(yī)學(xué)課件園www54meningioma醫(yī)學(xué)課件園meningioma醫(yī)學(xué)課件園55Hereisanotherbenignmeningiomabeneaththedura.Theseneoplasmsareslowgrowing,butmayreachalargesizebeforesymptomsleadtodetection.醫(yī)學(xué)課件園Hereisanotherbenignmeningi56Meningiomaofsphenoidwing醫(yī)學(xué)課件園Meningiomaofsphenoidwing醫(yī)學(xué)課57醫(yī)學(xué)課件園醫(yī)學(xué)課件園58醫(yī)學(xué)課件園醫(yī)學(xué)課件園59醫(yī)學(xué)課件園醫(yī)學(xué)課件園60From:Schwanncell大體:encapsul
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