Menin-MLL-inhibitor-20-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMenin-MLLinhibitor20Cat.No.:HY-128798CASNo.:2448173-47-3分?式:C??H??N?O?分?量:612.72作?靶點:EpigeneticReaderDomain作?通路:Epigenetics儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:33.33mg/mL(54.40mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.6321mL8.1603mL16.3207mL5mM0.3264mL1.6321mL3.2641mL10mM0.1632mL0.8160mL1.6321mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性Menin-MLLinhibitor20?種不可逆的menin-MLL相互作?的抑制劑，具有抗腫瘤活性(WO2020142557A1,compound6)。體外研究TheHistone-lysineN-methyltransferase2(KMT2)familyofproteins,whichcurrentlyconsistsofatleast5members,methylatelysine4onthehistoneH3tailsatimportantregulatoryregionsinthegenomeand1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEtherebyimpartcrucialfunctionsthroughthemodulationofchromatinstructuresandDNAaccessibility.Theseenzymesareknowntoplayanimportantroleintheregulationofgeneexpressionduringearlydevelopmentandhematopoiesis.ThehumanKMT2familywasinitiallynamedthemixed-lineageleukaemia(MLL)family,owingtotheroleofthefirst-foundmemberinthisdisease[1].REFERENCES[1].ThomasButler,etal.Irreversibleinhibitorsofmenin-mllinteraction.WO2020142557A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>