S-Adenosyl-L-methionine-tosylate-S-Adenosyl-methionine-tosylate-DataSheet-生命科學(xué)試劑-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemES-Adenosyl-L-methioninetosylateCat.No.:HY-B0617ASynonyms:S-Adenosylmethioninetosylate;Ademetioninetosylate;AdoMettosylate分?式:C??H??N?O?S?分?量:570.64作?靶點(diǎn):EndogenousMetabolite作?通路:MetabolicEnzyme/Protease儲(chǔ)存?式:-20°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)H2O:250mg/mL(438.10mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.7524mL8.7621mL17.5242mL5mM0.3505mL1.7524mL3.5048mL10mM0.1752mL0.8762mL1.7524mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。BIOLOGICALACTIVITY?物活性S-Adenosyl-L-methioninetosylate(S-Adenosylmethioninetosylate)通過蛋氨酸腺苷轉(zhuǎn)移酶的作?由蛋氨酸和ATP內(nèi)性?產(chǎn)的，?種重的具有?服活性的甲供體。S-Adenosyl-L-methioninetosylate?種具有有效的抗抑郁和鎮(zhèn)痛作?的膳?補(bǔ)充劑，并可?于肝病和?關(guān)節(jié)炎的研究。體外研究S-Adenosyl-L-methionine(Ademetionine)isinvolvedinthreemainmetabolicpathways:1)methylation,astheprincipalsourceofmethylgroupsinthebody;2)transsulfuration,S-Adenosyl-L-methionineformsS-Adenosylhomocysteine(SAH)andthenconvertedtohomocysteine(Hcy)whichcanbeconvertedtocystathioninethentocysteineandthesulfate(SO4)donatedtoothermetabolicintermediates;and3)1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEaminopropylation,asS-Adenosyl-L-methionineplaysanimportantroleinthesynthesisofpolyamineswhichcaneventuallyformandrecyclemethionine[2].InvitrostudiesusinghumanarticularchondrocyteshaveshownS-Adenosyl-L-methionine-inducedincreasesinproteoglycansynthesisandproliferationratesinrabbits[2].體內(nèi)研究Micelackingmethionineadenosyltransferase1a(Mat1a)havereducedhepaticS-Adenosyl-L-methioninelevelsanddevelopoxidativestress,steatohepatitis,andhepatocellularcarcinoma(HCC).However,injuryandHCCalsooccurifhepaticS-Adenosyl-L-methioninelevelisexcessivechronically.ThusanormalhepaticS-Adenosyl-L-methioninelevelisnecessarytomaintainliverhealthandpreventinjuryandHCC[3].?ResearchSquarePreprint.2020Aug.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].GMBressa.etal.S-adenosyl-l-methionine(SAMe)asantidepressant:meta-analysisofclinicalstudies.ActaNeurolScandSuppl.1994;154:7-14.[2].WadieINajm,etal.S-adenosylmethionine(SAMe)versuscelecoxibforthetreatmentofosteoarthritissymptoms:adouble-blindcross-overtrial.[ISRCTN36233495].BMCMusculoskeletDisord.2004Feb26;5:6.[3].ShellyCLu,etal.S-adenosylmethionineinliverhealth,injury,andcancer.PhysiolRev.2012Oct;92(4):1515-42.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalappli