E-Z-GSK5182-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemE(E/Z)-GSK5182Cat.No.:HY-111226A分?式:C??H??NO?分?量:417.54作?靶點(diǎn):EstrogenReceptor/ERR;ReactiveOxygenSpecies作?通路:Others;Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(239.50mM;Needultrasonic)H2O:<0.1mg/mL(insoluble)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.3950mL11.9749mL23.9498mL5mM0.4790mL2.3950mL4.7900mL10mM0.2395mL1.1975mL2.3950mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。BIOLOGICALACTIVITY?物活性(E/Z)-GSK5182(E)-GSK5182和(Z)-GSK5182的消旋體。GSK5182?種?效選擇性，具有?服活性的ERRγ反向激動(dòng)劑，其IC50值為79nM。GSK5182還能增加肝癌細(xì)胞中reactiveoxyenspecies(ROS)的產(chǎn)?。REFERENCES[1].KimJH,etal.Estrogen-relatedreceptorγisupregulatedinlivercanceranditsinhibitionsuppresseslivercancercellproliferationvia1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEinductionofp21andp27.ExpMolMed.2016Mar4;48:e213.[2].MisraJ,etal.ERRγ:aJuniorOrphanwithaSeniorRoleinMetabolism.TrendsEndocrinolMetab.2017Apr;28(4):261-272.[3].KimDK,etal.InverseagonistofnuclearreceptorERRγmediatesantidiabeticeffectthroughinhibitionofhepaticgluconeogenesis.Diabetes.2013Sep;62(9):3093-102.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax