11-Beta-hydroxyandrostenedione-4-Androsten-11β-ol-3-17-dione-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE11-Beta-hydroxyandrostenedioneCat. No.: HY-114464CAS No.: 382-44-5Synonyms: 4-Androsten-11-ol-3,17-dione分式: CHO分量: 302.41作靶點(diǎn): Endogenous Metabolite作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6

2、 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 250 mg/mL (826.69 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.3068 mL 16.5338 mL 33.0677 mL5 mM 0.6614 mL 3.3068 mL 6.6135 mL10 mM 0.3307 mL 1.6534 mL 3.3068 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 11-Beta-

3、hydroxyandrostenedione (4-Androsten-11-ol-3,17-dione)種主存在于腎上腺的類醇 (11-羥化酶存在于腎上腺組織，但在巢組織中不存在)。11-Beta-hydroxyandrostenedione種 11-羥基類醇脫氫酶 (11HSD) 同酶抑制劑。隨4-androstenedione 的增加，測(cè)量漿 11-Beta-hydroxyandrostenedione 可以區(qū)分雄激素癥的腎上腺或巢起。IC50 & Target Human Endogenous Metabolite1/2 Master of Small Molecules 您邊的抑制劑

4、師www.MedChemE體外研究 In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol(21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection ofCYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase

5、, 21dF and 21dE are infact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1,respectively 2.體內(nèi)研究 The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) isvery high in 21-hydroxylase deficiency, Cushings syndrome, and

6、 hyperandrogenism of adrenal origin, andvery low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level inorder to determine the adrenal or ovarian origin of the hyper

7、androgenism 1.REFERENCES1. Ibrahim F, et al. Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using abiotinylated tracer with a radioimmunoassay using a tritiated tracer. J Steroid Biochem Mol Biol. 2003 Apr;84(5):563-8.2. Rachelle Gent, et al. 11-Hydroxyprogesterone, a potent 11-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5-reductase and cytochrome P450 17hydroxylase/17,20-lyase to produce C11-derivatives of 21-deoxycortisolMcePdfHeightCaution: Product has not been fully validated for medical applications.For