MA-0204 - PPAR Modulator - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMA-0204Cat. No.: HY-114739CAS No.: 2095128-17-7分式: CHFNO分量: 476.49作靶點: PPAR作通路: Cell Cycle/DNA Damage儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 43.33 mg/mL (90.94 mM; Need ultrasonic)M

2、ass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.0987 mL 10.4934 mL 20.9868 mL5 mM 0.4197 mL 2.0987 mL 4.1974 mL10 mM 0.2099 mL 1.0493 mL 2.0987 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前

3、的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (4.55 mM); Suspended solution; Need ultrasonic2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.17 mg/mL (4.55 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活

4、性 MA-0204種有效，選擇性，有服活性的的過氧化物酶體增殖物激活受體 (PPAR) 調(diào)節(jié)劑，對于，和 PPAR 的 EC50 分別為 0.4 nM、7.9 nM 和 10 nM。有治療 Duchene 肌營養(yǎng)不良癥 (DMD) 的潛 1。IC50 & Target PPAR PPAR PPAR0.4 nM (EC50, in human) 7.9 nM (EC50, in mouse) 10 nM (EC50, in rat)體外研究 MA-0204 is 10,000-fold selective for activation of PPAR over PPAR and PPAR rec

5、eptors. MA-0204exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C 1.MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice 1.MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts 1.體內(nèi)研究 PPAR (

6、30, 100 mg/kg) increases target gene transcription in the muscle 1.REFERENCES1. Lagu B, et al. Selective PPAR Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy(DMD). ACS Med Chem Lett. 2018 Jul 31;9(9):935-940.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-