Exo1-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEExo1Cat. No.: HY-112670CAS No.: 75541-83-2分式: CHFNO分量: 273.26作靶點(diǎn): Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 25 mg/mL (91.49 mM; Need ultrasonic)H2O : 90% corn oilSolu

2、bility: 2.5 mg/mL (9.15 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Exo1exocytic pathway 的抑制劑。體外研究 Exo1 is a modifier of Golgi ARF1 GTPase activity. Because Exo1 affects a subset of the membrane events thatare blocked by BFA, but seems to have a differe

3、nt protein target (and presumably has different side effects), itprovides an independent means to interfere with Golgi activity. Exo1 Disrupts Vesicular Traffic from the ER tothe Golgi apparatus by disrupting Golgi structures. Exo1 inhibits exocytosis with an IC50 of 20 M. Exo1prevents acquisition o

4、f endoglycosidase H resistance by newly synthesized proteins such as VSVGts-GFP,transferrin, and MHC class I 1.REFERENCES1. Feng Y, et al. Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6469-74.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 02