Tezacaftor-VX-661-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETezacaftorCat. No.: HY-15448CAS No.: 1152311-62-0Synonyms: VX-661分式: CHFNO分量: 520.5作靶點(diǎn): CFTR作通路: Membrane Transporter/Ion Channel儲(chǔ)存式: 4C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解

2、性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (192.12 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.9212 mL 9.6061 mL 19.2123 mL5 mM 0.3842 mL 1.9212 mL 3.8425 mL10 mM 0.1921 mL 0.9606 mL 1.9212 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?/p>

3、先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.80 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.80 mM); Clear solution3. 請

4、依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (4.80 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Tezacaftor (VX-661)F508del CFTR 的矯正器，能夠幫助 CFTR 蛋與細(xì)胞表結(jié)合。體外研究 In vitro, a combination of Tezacaftor (VX-661) and ivacaftor results in greater CFTR activ

5、ity compared withTezacaftor (VX-661) alone 2.REFERENCES1. Treatment with VX-661 and Ivacaftor in a Phase 2 Study Resulted in Statistically Significant Improvements in Lung Function in Peoplewith Cystic Fibrosis Who Have Two Copies of the F508del Mutation. April 18, 2013McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-