Loreclezole-R-72063-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELoreclezoleCat. No.: HY-105272CAS No.: 117857-45-1Synonyms: R 72063分式: CHClN分量: 274.53作靶點(diǎn): GABA Receptor作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mo

2、nth溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 110 mg/mL (400.68 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (7.58 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (7.58 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性

3、Loreclezole種抗癲癇藥物，是選擇性的GABAA 受體 的調(diào)節(jié)劑，是2 或3亞單位包含受體的正向變構(gòu)調(diào)節(jié)劑。IC50 & Target GABAA receptor 1.REFERENCES1. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a singleamino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A

4、. 1994 May 10;91(10):4569-73.2. Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit.Neuropharmacology. 1996;35(12):1753-60.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-5