Maxacalcitol-22-Oxacalcitriol-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMaxacalcitolCat. No.: HY-32339CAS No.: 103909-75-7Synonyms: 22-Oxacalcitriol分式: CHO分量: 418.61作靶點: VD/VDR作通路: Vitamin D Related儲存式: 4C, protect from light, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (protec

2、t fromlight, stored under nitrogen)溶解性數據體外實驗 DMSO : 100 mg/mL (238.89 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.3889 mL 11.9443 mL 23.8886 mL5 mM 0.4778 mL 2.3889 mL 4.7777 mL10 mM 0.2389 mL 1.1944 mL 2.3889 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗 請根據您的實驗動物和

3、給藥式選擇適當的溶解案，配制前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.97 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.97 mM); Cl

4、ear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.97 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Maxacalcitol (22-Oxacalcitriol)鈣維素D3類似物和VDR樣受體的配體。戶使本產品發(fā)表的科研獻 Int J Mol Sci. 2017 Dec 19;18(12). pii: E2764. J Dermatol Sci. April. Eu

5、r J Pharmacol. 2016 Oct 5;788:98-103.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Barroga, et al. Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of a canine osteosarcoma derived cell-line invivo and its pulmonary metastasis in vivo. Res.Vet

6、.Sci. (2000)68 79.2. Monier-Faugere, et al. 22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renalfailure. Kidney Int. (1999)55 821.3. Inoue K, et al. Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex topSmad3.Lab Invest. 2012 Aug 27.4. Karashima T, et al. Successful Treatment of Bowens Disease with Topical Maxacalcitol.Acta Derm Venereol. 2012 Jan 26.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use onl