Chlorantraniliprole-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEChlorantraniliproleCat. No.: HY-112820CAS No.: 500008-45-7分式: CHBrClNO分量: 483.15作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 62.5 mg/mL (129.36 mM)H2O : 40% PEG300

2、5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.31 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.31 mM); Clear solution; Need warming1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Chlorantraniliprole種殺劑，能夠有效地、選擇性地激活蘭諾定受體 (ryanodine receptor)

3、，對(duì)腹果蠅和煙芽夜蛾的 ryanodine 受體 EC50 值分別為 40 nM 和 50 nM，對(duì)其選擇性 對(duì)骼肌 2C12 細(xì)胞ryanodine 受體 (EC50，14 M) 的 300 多倍。IC50 & Target EC50: 40 nM (Drosophila melanogaster Ryanodine receptor), 50 nM (H. virescens Ryanodine receptor), 14 M (Ryanodine receptor, in C2C12 cells)體外研究 Chlorantraniliprole is an insecticide tha

4、t potently and selectively activates insect ryanodine receptor.Chlorantraniliprole actions by release of intracellular Ca2+ stores mediated by the ryanodine receptor.Chlorantraniliprole is -300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line,C2C12 (EC50, 14 M), tha

5、n in insect RyRs from Drosophila melanogaster and H. virescens (EC50, 40 nM,50 nM), and shows little selectivity at the rat cell line RyR2 (EC50, 100 M) 1.體內(nèi)研究 Chlorantraniliprole has low acute mammalian toxicity with an acute oral LD50 of 5000 mg/kg in rats, andlittle to no toxicity in 90-day studi

6、es, at dosing as high as 1500 mg/kg/day 1.REFERENCES1. George P.Lahm, et al. Rynaxypyr: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.Bioorganic & Medicinal Chemistry Letters. 2007 Nov 15;17(22):6274-6279.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-