Tozadenant-SYN115-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETozadenantCat. No.: HY-10995CAS No.: 870070-55-6Synonyms: SYN115分式: CHNOS分量: 406.5作靶點: Adenosine Receptor作通路: GPCR/G Protein儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 50 mg/mL (123.00

2、mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.4600 mL 12.3001 mL 24.6002 mL5 mM 0.4920 mL 2.4600 mL 4.9200 mL10 mM 0.2460 mL 1.2300 mL 2.4600 mL請根據(jù)產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備

3、液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.15 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.15 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Mole

4、cules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (6.15 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Tozadenantadenosine A2A 受體拮抗劑，作于類和恒河猴的 adenosine A2A 受體，Ki 值分別為 11.5nM 和 6 nM。IC50 & Target Ki: 6 nM (Rhesus A2A), 11.5 nM (Human A2A)體內研究 18F-MNI-444 regional uptake is consistent with A2A receptor distri

5、bution in the brain. Selectivity isdemonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant 1.戶使本產品發(fā)表的科研獻 Molecules 2019, 24(7), 1295 PLoS One. 2019 Mar. PLoS One. 2016 Nov 11;11(11):e0166415.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Olivier Barret, et al. Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys. J Nucl Med. 2014Oct;55(10):1712-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37