N6-Methyladenosine-6-Methyladenosine-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEN6-MethyladenosineCat. No.: HY-N0086CAS No.: 1867-73-8Synonyms: 6-Methyladenosine; N-Methyladenosine分式: CHNO分量: 281.27作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 3

2、1 mg/mL (110.21 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.5553 mL 17.7765 mL 35.5530 mL5 mM 0.7111 mL 3.5553 mL 7.1106 mL10 mM 0.3555 mL 1.7777 mL 3.5553 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助

3、溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (7.40 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (7.40 mM); Clear solution1/2 Master of Smal

4、l Molecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (7.40 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 N6-Methyladenosine存在于所有等真核物中最 遍的的信使 RNA (mRNA) 內(nèi)部 (帽) 修飾。體外研究 N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) proteint

5、o regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in themessenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70)within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-contain

6、ing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion1. N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biologicalprocesses, including regulation of embryonic stem cell self-renewal and differentiation. N6-meth

7、yladenosine(m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) andmethyltransferase-like 14 (METTL14) catalytic subunits 2.REFERENCES1. Wang X, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20.2. Li Y, et al. Genome-wide detection of high abundance N6-methyladenosine sites by microarray. RNA. 2015 Aug;21(8):1511-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For rese