C-DIM12-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEC-DIM12Cat. No.: HY-19808CAS No.: 178946-89-9分式: CHClN分量: 356.85作靶點(diǎn): Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (280.23 mM)H2O : 0.1 mg/mL (insoluble)* means

2、 soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.8023 mL 14.0115 mL 28.0230 mL5 mM 0.5605 mL 2.8023 mL 5.6046 mL10 mM 0.2802 mL 1.4011 mL 2.8023 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 C-DIM12種合成的Nurr1激活劑, 誘導(dǎo)Nurr1和DA基因表達(dá)。REFERENCES1/2

3、 Master of Small Molecules 您邊的抑制劑師www.MedChemE1. De Miranda BR, et al. The Nurr1 Activator 1,1-Bis(3-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2Microglial Cells by Inhibiting Nuclear Factor B. Mol Pharmacol. 2015 Jun;87(6):1021-34. doi: 10.1124/mol.114.095398. Epub

4、2. Hammond SL, et al. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neurosci Lett. 2015 Oct 21;607:83-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-5