PROTAC-ERα-Degrader-2 _SNIPER - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPROTAC ER Degrader-2Cat. No.: HY-111846CAS No.: 1351169-29-3分式: CHNO分量: 763.96作靶點(diǎn): SNIPER; Estrogen Receptor/ERR; PROTAC作通路: PROTAC; Others儲存式: -20C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored unde

2、rnitrogen)溶解性數(shù)據(jù)體外實(shí)驗 DMSO : 200 mg/mL (261.79 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.3090 mL 6.5448 mL 13.0897 mL5 mM 0.2618 mL 1.3090 mL 2.6179 mL10 mM 0.1309 mL 0.6545 mL 1.3090 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗 請根據(jù)您的實(shí)驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液?/p>

3、再依次添加助溶劑(為保證實(shí)驗結(jié)果的可靠性，體內(nèi)實(shí)驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 5 mg/mL (6.54 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 5 mg/mL (6.54 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of

4、 Small Molecules 您邊的抑制劑師www.MedChemE物活性 PROTAC ER Degrader-2 包含 cIAP1 配體結(jié)合基團(tuán)，linker 和雌激素受體 (ER) 配體結(jié)合基團(tuán)。在 MCF7 細(xì)胞中，PROTAC ER Degrader-2 降低 ER 平，30 M 濃度時達(dá)到最降解程度。同時，基于 cIAP1 的降解劑也被稱為 SNIPER 1。REFERENCES1. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax