Mevastatin-Compactin-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMevastatinCat. No.: HY-17408CAS No.: 73573-88-3Synonyms: Compactin; ML236B分式: CHO分量: 390.51作靶點(diǎn): HMG-CoA Reductase (HMGCR); Autophagy作通路: Metabolic Enzyme/Protease; Autophagy儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 mon

2、ths-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 25 mg/mL (64.02 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.5608 mL 12.8038 mL 25.6075 mL5 mM 0.5122 mL 2.5608 mL 5.1215 mL10 mM 0.2561 mL 1.2804 mL 2.5608 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)

3、備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.40 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.40 mM); Clear solution3. 請(qǐng)依序添加每種溶

4、劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (6.40 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Mevastatin (Compactin; ML236B)抑制HMG-CoA還原酶（HMGCR），可抑制類異戊烯的物合成，阻斷蛋的異戊烯化，降低漿膽 醇平。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Eur Res J. March 20, 2018.See more customer validations on HYPERLI

5、NK / www.MedChemEREFERENCES1. Sugazaki M, Hirotani H, Echigo S, et al. Effects of mevastatin on grafted bone in MRL/MpJ mice. Connect Tissue Res. 2010Apr;51(2):105-12. doi: 10.3109/03008200903105098.2. Evangelopoulos ME, Weis J, Krttgen A. Mevastatin-induced neurite outgrowth of neuroblastoma cells

6、via activation of EGFR. JNeurosci Res. 2009 Jul;87(9):2138-44. doi: 10.1002/jnr.22025.3. W?chtersh?user A, Akoglu B, Stein J. HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in thecolorectal carcinoma cell line Caco-2. Carcinogenesis. 2001 Jul;22(7):1061-7.4.

7、 Amin-Hanjani S, Stagliano NE, Yamada M, et al. Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulatesendothelial nitric oxide synthase in mice. Stroke. 2001 Apr;32(4):980-6.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use on