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一、翻譯(共20分,每題1分)。1 Hexane2 Mercury3 Potassium4 Cysteine 5 Methionine6 Amide7 Ethyl acetate8 Potassium carbonate9 Sodium bicarbonate10 Pentane11 蘇氨酸12 腺苷酸13 氯14 碘 15 脯氨酸16 色氨酸 17 酮18 環(huán)己烷19 CaCO320 氯化鈉 答案:1 己烷2 汞3 鉀4 半胱氨酸5 甲硫氨酸6 酰胺7 乙酸乙酯8 碳酸鉀9 碳酸氫鈉10 戊烷11 Threonine12 Adenylic acid13 Chlorine14 Iodine15 Proline16 Tryptophan17 Acetone18 Cyclohexane19 Calcium carbonate20 Sodium chloride二、寫出下列縮寫的英文全稱并翻譯(共10分,每題2分)。1 QSAR: 2 TLC: 3 UV/visible: 4 MBA: 5 CEO: 答案:1 Quantitative Structure-Activity Relationship 定量構(gòu)效關(guān)系2 Thin Layer Chromatography 薄層層析法3 Ultraviolet-visible spectroscopy 紫外分光光度法4 Master (Management) of Business Administration 工商管理碩士5 Chief Executive Officer 首席執(zhí)行官三、判斷(共16分,每題2分),并用 表示。1 ( )Analytical chemists work to improve the reliability of existing techniques to meet the demands for better chemical measurements which arise constantly in our society.2 ( )A specific reaction or test is one that occur only with the substance of interest.3 ( )The lead compound is not intended to be used as a clinical agent.4 ( )Biomolecules are compounds of carbon.5 ( )Highly polar water-soluble drugs being transferred slowly whereas highly lipidsoluble, non-polar drugs are transferred rapidly across the lipid-rich membranes of cells.6 ( )The degree of aqueous solubility of the drug affects the rate of the dissolution.7 ( )Direct comparison with authentic (if available) should not be carried out as final confirmation.8 ( )Lead compounds can be obtained from a variety of different sources such as the flora and fauna of the natural world, or synthetic compounds made in the laboratory. There is also the potential of designing lead compounds using computer modeling or NMR spectroscopic studies.答案: 1 2 3 4 5 6 7 8 四、單選題(共14分,每題2分)。1 Quantitative analysis D with the determination of how much of one or more constituents is present.A do B research C seek D deal2 Presently, D , it is applied in a very general manner to synthetic as well as to natural compounds in the search for new lead compound.A UV B NMR C IR D HTS3 alcohols have one or more C groups A acetyl B aldehyde C hydroxyl D carboxyl4 C view of the complexity of the human body, it is inevitable that pharmacokinetic formulations must be based on drastically simplifying assumptions.A In B At C By D As5 A the temperature is maintained at a constant 37 , and the agitation of stirring rate is held to a specified constant. A In vivo B In vitro C In aqueous solution D In vacuum6 In UV A of the material are required, since the standard spectrophotometric cell only hold 3 mL of solution and, using special cells, only one tenth of this volume need be available for spectrophotometry.A only traces B many C little D much7 In the UK, only drug products and biological manufacturers (not A ; except some specified antibiotics) were inspected by the regulatory authority for compliance to GMP.A APIs B drug C manufacturers D OTCs答案: 1 D 2 D 3 C 4 C 5 A 6 A 7 A五、英譯漢(共20分,每題5分)。1 The four most abundant elements in living organisms, in terms of the percentage of the total number of atoms, are hydrogen, oxygen, nitrogen, and carbon, which together make up over 99% of the mass of most cells.答案: 四種含量最豐富的元素在生物體中的原子總數(shù)的百分比計(jì)算,是氫,氧,氮,碳,加起來(lái)超過(guò)全部細(xì)胞總重的99。2 A one-compartment model with first-order elimination often approximates the clinical situation surprisingly well once absorption and distribution have occurred.答案:當(dāng)吸收分布過(guò)程完成后,一個(gè)遵循一級(jí)消除的一室模型與臨床情況十分相似。3 Analytical chemists work to improve the reliability of existing techniques to meet the demands for better chemical measurements which arise constantly in our society.答案: 分析化學(xué)家的工作是改善現(xiàn)有技術(shù)的可靠性,以更好的化學(xué)檢測(cè)方法滿足我們社會(huì)不斷的需求。4 Solid drug products exempted from disintegration tests include troches, tablets which are intended to be chewed, and drug products intended for sustained release or prolonged or repeat action.答案: 免除崩解測(cè)試的固體藥品包括含片、咀嚼片和緩控釋釋放、長(zhǎng)效釋放、重復(fù)釋放制劑。六、問答題(共20分,每題5分)。1 According to the Noyes-Whitney equation, what may be influence the dissolution kinetics?答案: It can be seen from the Noyes-Whitney equation that dissolution kinetics may be influenced by the physicochemical characteristics of the drug, the formulation, and the solvent.2 If authentic material is not available, what should to be done for its identification?答案: Careful comparison with literature data many suffice for its identification.3 What is the selective reaction or test?答案: A selective reaction or test is one that can occur with other substances

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