EIPA-Standard-L593754-Standard-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEEIPA(Standard)Cat.No.:HY-101840RCASNo.:1154-25-2Synonyms:L593754(Standard);MH12-43(Standard);Ethylisopropylamiloride(Standard)分?式:C??H??ClN?O分?量:299.76作?靶點:TRPChannel;ProstaglandinReceptor;Autophagy;COX;Na+/H+Exchanger(NHE)作?通路:MembraneTransporter/IonChannel;NeuronalSignaling;GPCR/GProtein;Autophagy;Immunology/Inflammation儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性EIPA(Standard)EIPA的分析標準品。本產(chǎn)品?于研究及分析應?。EIPA(L593754)?種具有?服活性的TRPP3通道抑制劑，IC50為10.5μM。EIPA可通過抑制Na+/H+-exchanger3(NHE3)來促進?噬(autophagy)。EIPA也抑制巨胞飲作?(macropinocytosis)。EIPA可?于炎癥和癌癥的研究，如胃癌、結(jié)腸癌、胰腺癌[1][2][3][4][5][6][7]。IC50&TargetIC50:10.5μM(TRPP3)[1]NHE[2]Macropinocytosis[3]REFERENCES[1].DaiXQ,etal.InhibitionofTRPP3channelbyMK-870andanalogs.MolPharmacol.2007Dec;72(6):1576-85.[2].ShiH,etal.Na+/H+ExchangerRegulatesAminoAcid-MediatedAutophagyinIntestinalEpithelialCells.CellPhysiolBiochem.2017;42(6):2418-2429.[3].ZhuBY,etal.AnewHDACinhibitorcinnamoylphenazineshowsantitumoractivityinassociationwithintensivemacropinocytosis.[4].EVStelmashook,etal.Acidosisand5-(N-ethyl-N-isopropyl)amiloride(EIPA)AttenuateZinc/KainateToxicityinCulturedCerebellarGranuleNeurons.Biochemistry(Mosc).2015Aug;80(8):1065-72.[5].ShigekuniHosogi,etal.AninhibitorofNa(+)/H(+)exchanger(NHE),ethyl-isopropylamiloride(EIPA),diminishesproliferationofMKN28humangastriccancercellsbydecreasingthecytosolicCl(-)concentrationviaDIDS-sensitivepathways.CellPhysiolBiochem.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE2012;30(5):1241-53.[6].JunjiYamashita,etal.RoleofNa+/H+exchangerinthepathogenesisofischemicacuterenalfailureinmice.JCardiovascPharmacol.2007Mar;49(3):154-60.[7].FumitakaKamachi,etal.Inhibitionoflipopolysaccharide-inducedprostaglandinE2productionandinflammationbytheNa+/H+exchangerinhibitors.JPharmacolExpTher.2007Apr;321(1):345-52.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonl