Foretinib-phosphate-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEForetinibphosphateCat.No.:HY-10338ACASNo.:1226999-07-0分?式:C??H??F?N?O??P?分?量:828.64作?靶點:c-Met/HGFR;VEGFR作?通路:ProteinTyrosineKinase/RTK儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Foretinibphosphate?種具有潛在抗腫瘤活性的?服?物可利??分?。Foretinibphosphate能夠選擇性地抑制肝細胞?長因?（HGF）受體c-MET和?管內??長因?受體2（VEGFR2），從?可能抑制腫瘤的?管?成、腫瘤細胞增殖和轉移。Foretinibphosphate在肺癌細胞中顯?出與cabozantinib不同的抗癌活性，并且對MEK1/2、FER和AURKB等靶點具有更強的抑制作?。戶使?本產品發(fā)表的科研?獻?CancerDiscov.2021Jan;11(1):126-141.?NatBiomedEng.2018Aug;2(8):578-588.?SciTranslMed.2018Jul18;10(450).pii:eaaq1093.?CellChemBiol.2018Feb15;25(2):206-214.e11.?CellRepMethods.2023Oct23;3(10):100599.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].QianF,etal.Inhibitionoftumorcellgrowth,invasion,andmetastasisbyEXEL-2880(XL880,GSK1363089),anovelinhibitorofHGFandVEGFreceptortyrosinekinases.CancerRes,2009,69(20),8009-8016.[2].KataokaY,etal.Foretinib(GSK1363089),amulti-kinaseinhibitorofMETandVEGFRs,inhibitsgrowthofgastriccancercelllinesbyblockinginter-receptortyrosinekinasenetworks.InvestNewDrugs,2011.[3].EderJP,etal.AphaseIstudyofforetinib,amulti-targetedinhibitorofc-Metandvascularendothelialgrowthfactorreceptor2.Clin1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECancerRes,2010,16(13),3507-3516.[4].DivergentPolypharmacology-DrivenCellularActivityofStructurallySimilarMulti-KinaseInhibitorsthroughCumulativeEffectsonIndividualTargetsMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-