Tacrolimus-monohydrate-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemETacrolimusmonohydrate(Standard)Cat.No.:HY-13756ARCASNo.:109581-93-3分?式:C??H??NO??分?量:822.03作?靶點(diǎn):Phosphatase;FKBP;Autophagy;Bacterial;Antibiotic作?通路:MetabolicEnzyme/Protease;Apoptosis;Autophagy;CellCycle/DNADamage;Immunology/Inflammation;Anti-infection儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Tacrolimus(monohydrate)(Standard)Tacrolimus(monohydrate)的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Tacrolimusmonohydrate(FK506monohydrate)?環(huán)內(nèi)酯類(lèi)化合物，Tacrolimusmonohydrate與FK506結(jié)合蛋?(FKBP)結(jié)合形成復(fù)合物并抑制鈣調(diào)神經(jīng)磷酸酶(calcineurinphosphatase)，從?抑制T淋巴細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)和IL-2轉(zhuǎn)錄。具有強(qiáng)免疫抑制特性。IC50&TargetPP2B(calcineurinphosphatase)[1]Autophagyinducer[2]REFERENCES[1].ThomsonAW,etal.ModeofactionofTacrolimus(FK506):molecularandcellularmechanisms.TherDrugMonit.1995Dec;17(6):584-91.[2].VogelKR,etal.mTORinhibitorsrescueprematurelethalityandattenuatedysregulationofGABAergic/glutamatergictranscriptioninmurinesuccinatesemialdehydedehydrogenasedeficiency(SSADHD),adisorderofGABAmetabolism.JInheritMetabDis.2016Nov;39(6):877-886.[3].ZhuH,etal.TacrolimuspromoteshepatocellularcarcinomaandenhancesCXCR4/SDF1αexpressioninvivo.MolMedRep.2014Aug;10(2):585-92.[4].OkadaY,etal.Tacrolimusamelioratesdextransulfatesodium-inducedcolitisinmice:implicationofinterferon-γandinterleukin-1βsuppression.BiolPharmBull.2011;34(12):1823-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955