MO-I-1100-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMO-I-1100Cat.No.:HY-164410CASNo.:1585217-40-8分?式:C??H??ClNO?S分?量:379.81作?靶點:Notch作?通路:NeuronalSignaling;StemCell/Wnt儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性MO-I-1100ASPH(天冬氨酰-(天冬酰胺)-β-羥化酶)酶活性的抑制劑。MO-I-1100可抑制HCC細胞遷移、侵襲和錨定?依賴性?長。MO-I-1100通過抑制HCC中的Notch信號級聯(lián)?表現(xiàn)出抗腫瘤作?。體外研究MO-I-1100hasnoeffectonviabilityofNIH3T3cellswhichlackedASPHonthecellsurface[1].MO-I-1100(1-10μM)inhibitstheviabilityofFOCUScells,whichhavehighlevelASPHexpression[1].體內(nèi)研究MO-I-100(50mg/kg,ip,for5consecutivedaysperweekfor2weeksandthenadministeredeveryotherday)reducestumorgrowthinanintrahepaticorthotopicxenograftmodelofHCC[1].MO-I-1100(50mg/kg/day,ip,for5days)reducestheactivatedNotch1(cleavedfragment)aswellasdownstreamHES1andHEY1geneexpression[1].AnimalModel:Nudemicewithestablisheds.c.tumorxenograftsofFOCUScells[1]Dosage:50mg/kg/dayAdministration:Ip,for5daysResult:ReducedtheactivatedNotch1(cleavedfragment)aswellasdownstreamHES1andHEY1geneexpression.REFERENCES[1].AiharaA,etal.Acell-surfaceβ-hydroxylaseisabiomarkerandtherapeutictargetforhepatocellularcarcinoma.Hepatology.20141/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEOct;60(4):1302-13.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792a