CARM1-degrader-1-hydrochloride-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECARM1degrader-1hydrochlorideCat.No.:HY-156152A分?式:C??H??ClN??O?S分?量:1316.14作?靶點(diǎn):HistoneMethyltransferase;PROTACs作?通路:Epigenetics;PROTAC儲(chǔ)存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:6.67mg/mL(5.07mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM0.7598mL3.7990mL7.5980mL5mM0.1520mL0.7598mL1.5196mL10mM---------請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性CARM1degrader-1hydrochlorideCARM1degrader-1(HY-156152)的鹽酸鹽形式。CARM1degrader-1hydrochloride輔激活劑相關(guān)精氨酸甲轉(zhuǎn)移酶1(CARM1)的PROTAC降解劑，VHL和蛋?酶依賴地降解CARM1，DC50為8.1nM。CARM1degrader-1hydrochloride可抑制CARM1底物(如聚腺苷酸結(jié)合蛋?PABP1和BGR1相關(guān)因?BAF155)甲化并抑制乳腺癌細(xì)胞遷移[1]。REFERENCES1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1].XieH,etal.,DevelopmentofPotentandSelectiveCoactivator-AssociatedArginineMethyltransferase1(CARM1)Degraders.JMedChem.2023Sep28;66(18):13028-13042.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-5