Salidroside-Standard-Rhodioloside-Standard-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemESalidroside(Standard)Cat.No.:HY-N0109RCASNo.:10338-51-9Synonyms:Rhodioloside(Standard)分子式:C??H??O?分子量:300.31作用靶點(diǎn):ProlylEndopeptidase(PREP);mTOR;Apoptosis作用通路:MetabolicEnzyme/Protease;PI3K/Akt/mTOR;Apoptosis儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)H2O:≥100mg/mL(332.99mM)DMSO:100mg/mL(332.99mM;Needultrasonic)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.3299mL16.6495mL33.2989mL5mM0.6660mL3.3299mL6.6598mL10mM0.3330mL1.6649mL3.3299mLBIOLOGICALACTIVITY生物活性Salidroside(Standard)是Salidroside的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Salidroside(Rhodioloside)是一種脯氨酰內(nèi)肽酶(prolylendopeptidase)抑制劑。Salidroside可通過(guò)激活mTOR信號(hào)緩解腫瘤惡病質(zhì)小鼠模型中的惡病質(zhì)癥狀。Salidroside還能通過(guò)增強(qiáng)PINK1/Parkin介導(dǎo)的線粒體自噬來(lái)保護(hù)多巴胺能神經(jīng)元。IC50&TargetProlylendopeptidase[1]mTOR[2]1/3 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemE體外研究Salidroside(100μM)inhibitsprolylendopeptidase(PEP)activity(10.6±1.9%).Prolylendopeptidaseisanenzymethatplaysaroleinthemetabolismofproline-containingneuropeptidasewhichisrecognizedtobeinvolvedinlearningandmemory[1].Salidroside,oneofthemajorphenylpropanoidglycosidesfoundinR.?roseaL,isconsumedalmostdailyasanutritionalsupplementinmanycountriesandhasbeenidentifiedpossessingpotentialanti-fatigueandanoxia,anti-aging,andanti-Alzheimer'sdiseaseactivities.SalidrosidecanimprovemusclenutritionviaincreasingmTOR,p-mTOR,andMyHCexpression[2].SH-SY5Ycellsareexposedto0-600?μMMPP+for12-48?handtheresultsshowthatMPP+resultsinasignificantdecreaseofcellviabilityinaconcentrationandtime-dependentmanner.Cellsarepretreatedwith25-100?μMSalidroside(Sal)for24?handthenexposedto500?μMMPP+foranadditional24?h.Salidrosideconcentration-dependentlypreventsMPP+-induceddecreaseofcellviability.AnnexinV/PIstainingisacommonmethodforthedetectionofapoptoticcell.SalidrosidesignificantlydecreasesthenumberofAnnexinV/PI-stainedcellstreatedbyMPP+whichisinaconcentration-dependentmanner.ApoptoticcellcouldalsobemorphologicallyevaluatedbyHoechststaining.InHoechststaining,apoptoticcellsarecharacterizedbyreducednuclearsize,chromatincondensation,intensefluorescence,andnuclearfragmentation.SalidrosidenotablyinhibitsMPP+-inducedincreaseofchromatincondensation,intensefluorescence,andnuclearfragmentationinSH-SY5Ycells[3].體內(nèi)研究SalidrosideisanaturalantioxidantextractedfrommedicinalfoodplantRhodiolarosea.Salidroside(100mg/kg/day)showsstrongglucoseloweringeffectondb/dbmicewhichissimilartoeffectofMetformin(200mg/kg/day)[4].Salidrosidecanbeusedtoinducetesticularinjurymodelinmice[6].客戶使用本產(chǎn)品發(fā)表的科研文獻(xiàn)ChemEngJ.1May2022,135115.Phytomedicine.2022Jan29;99:153964.FreeRadicBiolMed.2024Feb2:214:54-68.IntImmunopharmacol.2023Mar20;117:109975.FrontPharmacol.2020Nov11;11:580407.Seemorecustomervalidationsonwww.MedChemEREFERENCESWangZ,etal.SalidrosideAmelioratesFuran-InducedTesticularInflammationinRelationtotheGut-TestisAxisandIntestinalApoptosis.JAgricFoodChem.2023Nov9.LiR,etal.SalidrosideProtectsDopaminergicNeuronsbyEnhancingPINK1/Parkin-MediatedMitophagy.OxidMedCellLongev.2019Sep10;2019:9341018.FanW,etal.ProlylendopeptidaseinhibitorsfromtheundergroundpartofRhodiolasachalinensis.ChemPharmBull(Tokyo).2001Apr;49(4):396-401.JuL,etal.Salidroside,ANaturalAntioxidant,Improvesβ-CellSurvivalandFunctionviaActivatingAMPKPathway.FrontPharmacol.2017Oct18;8:749.2/3 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemEChenX,etal.SalidrosidealleviatescachexiasymptomsinmousemodelsofcancercachexiaviaactivatingmTORsignalling.JCachexiaSarcopeniaMuscle.2016May;7(2):225-32.WuL,etal.SalidrosideProtectsagainstMPP+-InducedNeuronalInjurythroughDJ-1-Nrf2AntioxidantPathway.EvidBasedComplementAlternatMed.2017;2017:5398542.Mce