病原微生物學(xué)課件：20-Rabies virus,Human papillomavirus,Poxvirus and human parvovirus B19,Prion

Rabiesvirus

Humanpapillomavirus

PoxvirusandhumanparvovirusB19

PrionSectionA

RabiesvirusBiologicalProperties

Rhabdoviridae(彈狀病毒科),Lyssavirus(狂犬病病毒屬).SsRNA,envelopedvirusWidehostrange.SingleserotypeAnimalsusceptibility

widehostrange:Allwarm-bloodedanimals溫血?jiǎng)游飛idelydistributedinanimalsnervoussystemsalivaurinelymphmilkblood

PathogenesisandImmunity

Source：

rabidanimal患病動(dòng)物（狂犬）

disease：

rabies，

hydrophobia狂犬?。炙。゛nacute，fulminant，fatalencephalitis急性爆發(fā)性致死性腦炎

Transmissionroute：

BiteofarabidanimalPathogenesisandImmunity

Spreadthroughnervesystem.NegribodyAcute,fatalencephalitis(致死性腦炎).Theclinicalspectrumcanbedividedintothreephases.Thetypicallesioninhuman’sbrain:Negribodynonspecificsymptoms：malaise，anorexia，headache，photophobia，nauseaandvomiting，sorethroat，andfever

nervoussystemdysfunction:

nervousness,apprehension,hallucination,hydrophobia

ThedevelopmentofrabiesvirusinvivoTreatmentandPreventionNosuccessfultreatmentforclinicalrabies.Themortalityofthediseaseis100%immediateandthoroughcleansing

迅速處理傷口20%皂水——70%酒精rabiesimmuneglobulin高效價(jià)抗狂犬病毒血清Killed-virusvaccineisadministeredintramuscularlyonthedayofexposureandtheondays3，7，14，and28.SectionB

PAPILLOMAVIRUSESBiologicalProperties

Papovaviridaefamily55nmindiameter.Double-strandedDNAenclosedwithinanonenvelopedcapsid.Artificialcultivationun-successful.PathogenesisandImmunity

Highlytropic(高度親嗜性)forepithelialcellsoftheskinandmucousmembranes.HPVtype16and18areconsideredtobehighcancerrisk.Cell-mediatedimmunity.OralWartsHumanPapillomavirusesSectionE

PrionBiologicalPropertiesLacksdetectablenucleicacidsPrPsc(scrapieprionprotein[羊搔癢癥朊粒蛋白])PrPc（cellularprionprotein[細(xì)胞朊粒蛋白]).Unusuallyresistanttostandardmeansofinactivation.BiologicalPropertiesPathogenesisandImmunityDirectContactNormalPrionProteinsPrionproteincontactrecruitsnormalproteinintoabnormalconformationsAbnormalPrionProteinNormalPrionProteinsAbnormalPrionProteinPathogenesisandImmunity

Transmissiblespongiformencephalopathies:auniquegroupoffatalneuordegenrativedisorders致死性中樞神經(jīng)系統(tǒng)的慢性退化性疾患Longincubationperiods（monthstodecades）

長(zhǎng)潛伏期chronicprogressivepathology（weekstoyears）

慢性進(jìn)行性Clinicalfindings1.HumanPrionDiseases:(1)Creutzfeldt-JakobDisease(CJD)(克雅病)(2)VariantCreutzfeldt-JakobDisease(vCJD)(克雅病變種)(3)Gerstmann-Straussler-ScheinkerSyndrome(GSS綜合征)(4)FatalFamilialInsomnia(致死性家族性失眠)(5)Kuru(庫(kù)魯病或顫抖病)2.AnimalPrionDiseases:(1)BovineSpongiformEncephalopathy(BSE)(牛海綿狀腦病或瘋牛病)(2)ChronicWastingDisease(CWD)(慢性消耗性疾病)(3)Scrapie(羊搔癢病)(4)Felinespongiformencephalopathy(貓海綿狀腦病)(5)Ungulatespongiformencephalopathy(有蹄類(lèi)海綿狀腦病)LaboratoryDiagnosis

Theclinicalpictu