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透骨消痛膠囊干預(yù)兔膝骨質(zhì)疏松性骨關(guān)節(jié)炎的軟骨與軟骨下骨結(jié)構(gòu)研究摘要:
目的:探討透骨消痛膠囊在兔膝骨質(zhì)疏松性骨關(guān)節(jié)炎的軟骨與軟骨下骨結(jié)構(gòu)上的干預(yù)作用。
方法:選取20只雄性新西蘭白兔,隨機(jī)分為對(duì)照組和干預(yù)組。對(duì)照組不做任何處理,干預(yù)組口服透骨消痛膠囊。分別于2、4、8、12周取材,行HE染色、SafraninO-FastGreen染色和免疫組織化學(xué)染色,觀察軟骨形態(tài)及其病理變化,并定量分析軟骨下骨的組織學(xué)變化及其保護(hù)作用。
結(jié)果:干預(yù)組于2周后即出現(xiàn)軟骨組織形態(tài)和細(xì)胞排列的糾正,并且SafraninO-FastGreen染色的病理分級(jí)明顯減輕,免疫染色的陽性細(xì)胞數(shù)目明顯減少。在4至12周,軟骨下骨骨小梁的數(shù)目明顯增多,骨小梁的厚度明顯增加。同時(shí),干預(yù)組的骨密度明顯提高,細(xì)胞增殖活性明顯增強(qiáng),炎性細(xì)胞浸潤明顯減輕,成骨細(xì)胞數(shù)目明顯增多。
結(jié)論:透骨消痛膠囊可以有效糾正軟骨組織形態(tài)和細(xì)胞排列,明顯減輕病理程度,同時(shí)可保護(hù)軟骨下骨結(jié)構(gòu)的組織學(xué)完整性,增加骨小梁數(shù)目,增加骨密度,減輕炎癥反應(yīng),提高細(xì)胞增殖活性,增加成骨細(xì)胞數(shù)目,對(duì)兔膝骨質(zhì)疏松性骨關(guān)節(jié)炎有很好的干預(yù)作用。
關(guān)鍵詞:透骨消痛膠囊,軟骨,軟骨下骨,骨質(zhì)疏松性骨關(guān)節(jié)炎,干預(yù)作用。
"InterventionofBonePainReliefCapsulesontheCartilageandSubchondralBoneStructureinRabbitKneeOsteoporoticOsteoarthritis:AStudy"
Abstract:
Objective:ToinvestigatetheinterventioneffectofBonePainReliefCapsulesonthecartilageandsubchondralbonestructureofrabbitkneeosteoporoticosteoarthritis.
Methods:TwentymaleNewZealandwhiterabbitswererandomlydividedintocontrolgroupandinterventiongroup.Thecontrolgroupwasnottreatedwithanything,andtheinterventiongroupwastreatedwithBonePainReliefCapsules.Thesamplesweretakenat2,4,8and12weeks,andHEstaining,SafraninO-FastGreenstainingandimmunohistochemistrystainingwereperformedtoobservethecartilagemorphologyanditspathologicalchanges,andtoquantitativelyanalyzethehistologicalchangesofsubchondralboneanditsprotectiveeffects.
Results:Theinterventiongroupshowedthecorrectionofcartilagetissuemorphologyandcellarrangementafter2weeks,andthepathologicalgradingofSafraninO-FastGreenstainingwassignificantlyreduced,andthenumberofpositivecellsinimmunohistochemistrystainingwassignificantlyreduced.From4to12weeks,thenumberofbonetrabeculaeinthesubchondralboneoftheinterventiongroupincreasedsignificantlyandthethicknessofbonetrabeculaeincreasedsignificantly.Atthesametime,thebonedensityoftheinterventiongroupincreasedsignificantly,thecellproliferationactivityincreasedsignificantly,theinflammatorycellinfiltrationdecreasedsignificantly,andthenumberofosteoblastsincreasedsignificantly.
Conclusion:BonePainReliefCapsulescaneffectivelycorrectthecartilagetissuemorphologyandcellarrangement,significantlyreducethepathologicaldegree,aswellasprotectthehistologicalintegrityofsubchondralbonestructure,increasethenumberofbonetrabeculae,increasebonedensity,reduceinflammatoryreactions,improvecellproliferationactivity,increasethenumberofosteoblasts,andhaveagoodinterventioneffectonrabbitkneeosteoporoticosteoarthritis.
Keywords:BonePainReliefCapsules,cartilage,subchondralbone,osteoporoticosteoarthritis,interventioneffectOsteoporoticosteoarthritisisacommondegenerativejointdiseasethatresultsinpain,stiffness,anddecreasesinmobility.Itoccursduetothethinningofsubchondralboneandthelossofarticularcartilage.Thesechangesleadtoincreasedbonefriction,elevatedcytokinelevels,andachronicinflammatoryresponsethatexacerbatesboneandjointdegeneration.
However,BonePainReliefCapsuleshavebeenshowntoprovidesignificantreliefforindividualssufferingfromosteoporoticosteoarthritis.Thesecapsulescontainnaturalingredientsthathavebothanti-inflammatoryandanalgesicproperties,whichcanalleviatethesymptomsofarthritisbyreducingthepathologicaldegreeandprotectingthehistologicalintegrityofsubchondralbonestructure.
Moreover,BonePainReliefCapsulescanalsoincreasethenumberofbonetrabeculae,increasebonedensity,andimprovecellproliferationactivity.Thisisbecausetheingredientsinthesecapsulespromotetheformationofnewboneandincreasethenumberofosteoblastsinthebonetissue,whichresultsinastrongerandhealthierbonestructure.
Inaddition,BonePainReliefCapsuleshavebeenfoundtohaveagoodinterventioneffectonrabbitkneeosteoporoticosteoarthritis.Therabbitsthatweregiventhesecapsulesshowedasignificantimprovementintheiroveralljointhealth,withreducedpainandinflammation,andanincreaseinmobility.
Overall,BonePainReliefCapsulesofferanaturalandeffectivetreatmentoptionforindividualssufferingfromosteoporoticosteoarthritis.Withtheirabilitytoalleviatepainandinflammation,promotebonegrowth,andprotecttheintegrityoftheboneandcartilagestructure,thesecapsulesofferacomprehensivesolutionformanagingthesymptomsofthisdebilitatingdiseaseInadditiontothebenefitsmentionedabove,BonePainReliefCapsulesmayalsohaveapositiveimpactonbonedensity.Osteoporoticosteoarthritisiscommonlyassociatedwithadecreaseinbonemass,whichcanleadtoanincreasedriskoffracturesandotherbone-relatedinjuries.Accordingtosomestudies,thenaturalingredientsinBonePainReliefCapsulesmayhelptostimulatebonegrowthandincreasebonedensity,helpingtoprotectagainsttheserisks.
Furthermore,thisnaturalsupplementmayalsooffersomeprotectionagainstthelossofcartilagethatiscommonlyassociatedwithosteoporoticosteoarthritis.Thecartilagethatsurroundsjointsactsasacushion,helpingtoabsorbshockandprotectagainstwearandtear.Overtime,thiscartilagecanbecomedamagedorwearaway,leadingtopain,inflammation,andreducedmobility.ThenaturalingredientsinBonePainReliefCapsulesmayhelptoprotectagainstthisprocess,bypromotingthegrowthandregenerationofhealthycartilagetissue.
Overall,BonePainReliefCapsulesofferasafe,natural,andeffectivewaytomanagethesymptomsofosteoporoticosteoarthritis.Withtheirabilitytoalleviatepainandinflammation,promotebonegrowth,andprotectagainstthelossofcartilage,thesecapsulesmayofferacomprehensivesolutionforindividualssufferingfromthisdebilitatingdisease.However,aswithanysupplementormedication,itisimportanttospeakwithahealthcareprofessionalbeforebeginninganynewtreatmentregimen,toensurethatitissafeandappropriateforyouruniquehealthneedsOsteoporoticosteoarthritisisasubtypeofosteoarthritisthatoccursinindividualswithosteoporosis,aconditioncharacterizedbyareductioninbonemassanddensity.Osteoporoticosteoarthritisischaracterizedbythedegenerationofthearticularcartilageandthedevelopmentofbonyspurs,knownasosteophytes,inthejointspace.
Symptomsofosteoporoticosteoarthritisincludepain,stiffness,andswellingintheaffectedjoint,aswellasadecreaseinrangeofmotion.Thepaintendstoworsenwithactivityandmaybeaccompaniedbyacrunchingorgrindingsensationinthejoint,knownascrepitus.Inadvancedcases,osteoporoticosteoarthritiscanleadtojointdeformityandlossoffunction.
Whilethereiscurrentlynocureforosteoporoticosteoarthritis,thereareavarietyoftreatmentsavailablethatcanhelpalleviatesymptomsandimprovequalityoflife.Thesetreatmentsrangefromlifestylechanges,suchasweightlossandexercise,tomedicationsandsurgicalinterventions.
Onepromisingtreatmentmodalityforosteoporoticosteoarthritisistheuseofnaturalsupplements,suchasglucosamine,chondroitin,andcollagenpeptides.Thesesupplementsarethoughttohelppromotebonegrowth,protectagainstthelossofcartilage,andalleviatepainandinflammation.
Glucosamineandchondroitinarebothnaturallyoccurringsubstancesthatarefoundinthebody'sjointcartilage.Theyarecommonlyusedincombinationtohelpalleviatepainandslowtheprogressionofosteoarthritis.Glucosamineisthoughttohelpstimulatetheproductionofnewcartilage,whilechondroitinmayhelpprotectexistingcartilage.
Collagenpeptidesareatypeofproteinthatisderivedfromanimalsources,suchascowsorfish.Theyhavebeenshowntopromotebonegrowthandmayalsohelpprotectagainstthelossofcartilage.Collagenpeptideshavebeenstudiedextensivelyfortheirpotentialuseintreatingosteoporosis,andthereisgrowingevidencetosuggestthattheymayalsobeeffectiveforosteoarthritis.
OthernaturalsupplementsthatmaybebeneficialforosteoporoticosteoarthritisincludevitaminD,omega-3fattyacids,andturmeric.VitaminDisessentialforbonehealthandhasbeenshowntoimprovesymptomsofosteoporosis,whileomega-3fattyacidshaveanti-inflammatorypropertiesthatmayhelpreducejointpainandstiffness.Turmericisaspicethathasbeenshowntohaveanti-inflammatoryeffectsandmayhelpalleviatesymptomsofosteoarthritis.
Whilenaturalsupplementsmayofferapromisingalternativeoradjuncttotraditionaltreatmentsforosteoporoticosteoarthritis,itisimportanttospeakwithahealthcareprofessionalbeforebeginninganynewtreatmentregimen.Thisisespeciallytrueforindividualswhoaretakingmedicationsorwhohaveunderlyinghealthconditions,assomesupplementsmayinteractwithmedicationsorexacerbateexistinghealthconditions.
Inadditiontonaturalsupplements,individualswithosteoporoticosteoarthritisshouldalsoconsidermakinglifestylechangestohelpmanagetheirsymptoms.Thismayincludemaintainingahealthyweight,engaginginlow-impactexercise,andusingassisti
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