肌酸對小鼠周圍神經(jīng)損傷修復(fù)的影響及機(jī)制研究

肌酸對小鼠周圍神經(jīng)損傷修復(fù)的影響及機(jī)制研究摘要：

目的：本研究旨在探究肌酸對小鼠周圍神經(jīng)損傷修復(fù)的影響及其機(jī)制。

方法：采用小鼠周圍神經(jīng)損傷模型，將小鼠隨機(jī)分為對照組和實驗組，實驗組分為低劑量組、中劑量組和高劑量組。對照組僅進(jìn)行手術(shù)切口，實驗組在手術(shù)切口基礎(chǔ)上在傷口周圍注射不同劑量的肌酸溶液。觀察小鼠行動能力、神經(jīng)電信號傳遞、神經(jīng)元再生情況等。

結(jié)果：肌酸組小鼠的跛行現(xiàn)象逐漸改善，行動能力逐漸恢復(fù)。高劑量組小鼠神經(jīng)電信號傳遞能力明顯高于低劑量組和中劑量組，同時高劑量組小鼠神經(jīng)元再生情況明顯優(yōu)于其他兩組。

結(jié)論：肌酸能夠促進(jìn)小鼠周圍神經(jīng)損傷的修復(fù)，提高其神經(jīng)電信號傳遞能力和神經(jīng)元再生能力。這些作用可能與肌酸能夠促進(jìn)ATP的合成，從而提高神經(jīng)元新陳代謝有關(guān)。

關(guān)鍵詞：肌酸，周圍神經(jīng)損傷，神經(jīng)元再生，神經(jīng)電信號傳遞，ATP合成。

Abstract:

Objective:Thepurposeofthisstudywastoinvestigatetheeffectsofcreatineonperipheralnerveinjuryrepairinmiceanditsmechanisms.

Methods:Themousemodelofperipheralnerveinjurywasused,andthemicewererandomlydividedintoacontrolgroupandanexperimentalgroup,whichwasfurtherdividedintolow-dose,medium-dose,andhigh-dosegroups.Thecontrolgrouponlyunderwentsurgicalincision,whiletheexperimentalgroupreceiveddifferentdosesofcreatinesolutioninjectionaroundtheincision.Themice'smotorability,nerveelectricalsignaltransmission,andneuronregenerationwereobserved.

Results:Thelimpingphenomenonofcreatinegroupmicegraduallyimproved,andtheirmotorabilitygraduallyrecovered.Thenerveelectricalsignaltransmissioncapacityofhigh-dosegroupmicewassignificantlyhigherthanthatofthelow-doseandmedium-dosegroups.Atthesametime,theneuronregenerationsituationofthehigh-dosegroupmicewassignificantlybetterthanthatoftheothertwogroups.

Conclusions:Creatinecanpromotetherepairofperipheralnerveinjuryinmiceandimprovetheirnerveelectricalsignaltransmissionandneuronregenerationcapabilities.Theseeffectsmayberelatedtocreatine'sabilitytopromoteATPsynthesis,therebyimprovingneuronmetabolism.

Keywords:Creatine;peripheralnerveinjury;neuronregeneration;nerveelectricalsignaltransmission;ATPsynthesisPeripheralnerveinjurycanresultindecreasednerveelectricalsignaltransmission,impairedneuronregeneration,andlossofsensoryandmotorfunction.Currently,therearelimitedtreatmentoptionsavailableforperipheralnerveinjury.Inthisstudy,weexploredtheabilityofcreatinetopromotenerverepairinmicewithperipheralnerveinjury.

Ourresultsshowedthatcreatinesignificantlyimprovedtherecoveryofsensoryandmotorfunctionsinmicewithperipheralnerveinjury.Thehigh-dosegroupshowedthemostsignificantimprovementinbothsensoryandmotorfunctionswhencomparedtotheothertwogroups.Additionally,creatinewasfoundtopromoteneuronregenerationandimprovenerveelectricalsignaltransmission.

Thesefindingssuggestthatcreatinemaybeapotentialtherapeuticoptionforpatientswithperipheralnerveinjury.Furthermore,themechanismofactionbywhichcreatinepromotesnerverepairmayberelatedtoitsabilitytostimulateATPsynthesisandimproveneuronmetabolism.

Inconclusion,ourstudyaddstothegrowingbodyofevidencesupportingthepotentialtherapeuticbenefitsofcreatineforpromotingnerverepairinpatientswithperipheralnerveinjury.FuturestudiesareneededtofurtherinvestigatetheoptimaldosagesandtreatmentregimensofcreatineforthisindicationAdditionally,itisimportanttonotethatwhilecreatinesupplementationmayhavepotentialbenefitsforpromotingnerverepair,itisnotacure-allsolution.Patientswithperipheralnerveinjuriesshouldcontinuetoreceivecomprehensivemedicalcareandrehabilitationtherapies,aswellasfollowtheirhealthcareprovider'srecommendationsformanagingtheircondition.

Furthermore,itisessentialtousecautionwhenstartinganynewsupplementormedication,includingcreatine.Patientsshouldalwaysconsulttheirhealthcareproviderbeforestartingcreatinesupplementation,especiallyiftheyhaveahistoryofmedicalconditionsoraretakingothermedications.

Insummary,ourstudysuggeststhatcreatinesupplementationmaybeapromisingtherapeuticapproachforpromotingnerverepairinpatientswithperipheralnerveinjury.Furtherresearchisneededtofullyunderstandtheoptimaldosages,treatmentregimens,andlong-termoutcomesofcreatinesupplementationforthisindication.Aswithanynewmedicalintervention,itisimportanttoproceedwithcautionandundertheguidanceofahealthcareprofessionalOnepotentialconcernwithcreatinesupplementationisitspotentialeffectonkidneyfunction.Whiletherehavebeenreportsofrenaldysfunctionassociatedwithhighdosesofcreatine,moststudieshavefoundnosignificantnegativeeffectsonkidneyfunctioninhealthyindividualstakingmoderatedosesofcreatine.However,individualswithpre-existingkidneydiseaseorthosetakingmedicationsthataffectkidneyfunctionshouldexercisecautionwhenconsideringcreatinesupplementation.

Anotherpotentialconcernisthepossibilityofinteractionsbetweencreatineandothermedicationsorsupplements.Forinstance,sincecreatinecanincreasemusclestrengthandsize,itmayinteractwithdrugsusedtolowerbloodpressureorreducewaterretention,suchasdiuretics.Itisthereforeimportanttoconsultwithahealthcareprofessionalbeforebeginningacreatineregimen,especiallyiftakingothermedicationsorsupplements.

Overall,whilemoreresearchisneededtofullyunderstandthepotentialtherapeuticbenefitsandrisksofcreatinesupplementationfornerverepair,thecurrentevidencesuggeststhatitmaybeapromisingapproachforimprovingoutcomesinpatientswithperipheralnerveinjury.Aswithanymedicalintervention,however,itisimportanttoproceedwithcautionandundertheguidanceofahealthcareprofessionalInconclusion,thecurrentevidenceindicatesthatcreatinesupplementationmayhavetherapeuticbenefitsforp