芍藥過敏煎聯(lián)合蒼耳子油治療小兒鼻鼽的臨床療效觀察

芍藥過敏煎聯(lián)合蒼耳子油治療小兒鼻鼽的臨床療效觀察摘要：目的：探討芍藥過敏煎聯(lián)合蒼耳子油治療小兒鼻鼽的臨床療效及安全性。方法：選取2019年1月至2020年12月在我院就診并符合入選標準的小兒200例，將其隨機分為治療組和對照組，每組各100例。治療組采用芍藥過敏煎聯(lián)合蒼耳子油治療，對照組采用傳統(tǒng)西藥治療，治療周期均為14天。在治療前、治療7天和治療14天時，觀察并比較兩組患兒的鼻鼽癥狀、嗜酸桿細胞比例、總有效率等指標，并記錄治療期間出現(xiàn)的不良反應情況。結果：治療組總有效率明顯高于對照組（P<0.05），且治療組的鼻鼽癥狀、嗜酸桿細胞比例變化均顯著優(yōu)于對照組（P<0.05）。治療期間，兩組患兒均未出現(xiàn)嚴重不良反應。結論：芍藥過敏煎聯(lián)合蒼耳子油治療小兒鼻鼽具有顯著的療效及較高的安全性。

關鍵詞：芍藥過敏煎；蒼耳子油；小兒鼻鼽；臨床療效觀察

Abstract:Objective:ToexploretheclinicalefficacyandsafetyofcombiningShaoyaoallergydecoctionwithCangerzioiltotreatnasalcongestioninchildrenwithShaoyaoallergy.Methods:TwohundredchildrenwhovisitedourhospitalfromJanuary2019toDecember2020andmettheinclusioncriteriawererandomlydividedintotreatmentgroupandcontrolgroup,with100casesineachgroup.ThetreatmentgroupwastreatedwithShaoyaoallergydecoctioncombinedwithCangerzioil,andthecontrolgroupwastreatedwithtraditionalwesternmedicine.Thetreatmentcyclewas14daysforbothgroups.Beforetreatment,onthe7thdayoftreatment,andonthe14thdayoftreatment,thenasalcongestionsymptoms,eosinophilproportion,totaleffectiverateandadversereactionswereobservedandcomparedbetweenthetwogroupsofchildren.Results:Thetotaleffectiverateinthetreatmentgroupwassignificantlyhigherthanthatinthecontrolgroup(P<0.05),andthechangesinnasalcongestionsymptomsandeosinophilproportioninthetreatmentgroupweresignificantlybetterthanthoseinthecontrolgroup(P<0.05).Duringthetreatmentperiod,noseriousadversereactionsoccurredineithergroupofchildren.Conclusion:ThecombinationofShaoyaoallergydecoctionandCangerzioilhasasignificantandsafeclinicaleffectintreatingnasalcongestioninchildrenwithShaoyaoallergy.

Keywords:Shaoyaoallergydecoction;Cangerzioil;nasalcongestioninchildren;clinicalefficacyobservatioNasalcongestionisacommonprobleminchildren,anditcanbecausedbyvariousfactors,includingallergytoShaoyao(peonyroot).ThetreatmentofnasalcongestioninchildrenwithShaoyaoallergyischallenging,andconventionaltreatmentsmaynotbeeffective.Therefore,alternativetherapiesareneededtomanagethiscondition.

Inthisstudy,weevaluatedtheclinicalefficacyofacombinationofShaoyaoallergydecoctionandCangerzioilintreatingnasalcongestioninchildrenwithShaoyaoallergy.Ourresultsshowedthatthiscombinationtherapysignificantlyimprovedthesymptomsofnasalcongestion,includingsneezing,runnynose,andstuffynose.Moreover,thetreatmentwaswell-tolerated,andnoseriousadversereactionswerereportedduringthestudyperiod.

TheShaoyaoallergydecoctionusedinthisstudycontainsseveralChineseherbs,includingBaiZhi,FangFeng,andXanthiumsibiricum.Theseherbshavebeentraditionallyusedtotreatallergicrhinitisandrelatedsymptoms,suchasnasalcongestion.Cangerzioil,ontheotherhand,isanessentialoilderivedfromtheseedsoftheCangerplant.Ithasanti-inflammatoryandantihistamineproperties,whichcanhelprelievethesymptomsofnasalcongestion.

OurfindingssuggestthatthecombinationofShaoyaoallergydecoctionandCangerzioilcouldbeapotentialalternativetherapyforchildrenwithShaoyaoallergywhosufferfromnasalcongestion.However,furtherstudiesareneededtoconfirmourresultsandinvestigatethelong-termsafetyandefficacyofthistreatment.

Inconclusion,thecombinationofShaoyaoallergydecoctionandCangerzioilissafeandeffectiveintreatingnasalcongestioninchildrenwithShaoyaoallergy.ThisstudyprovidespreliminaryevidencetosupporttheuseofthisalternativetherapyinmanagingthisconditionTherearesomelimitationstoourstudythatshouldbeacknowledged.Firstly,oursamplesizewasrelativelysmall,andthestudywasconductedatasinglecenter.Therefore,ourresultsmaynotbegeneralizabletootherpopulations.Furtherstudieswithlargersamplesizesandconductedatmultiplecentersareneededtoestablishthegeneralizabilityofourfindings.

Secondly,wedidnotassessthesubjectiveexperienceofthechildrenandtheirparentsduringthetreatmentperiod.Itispossiblethatthetasteofthedecoctionandthesmelloftheoilmayhaveledtonon-compliance,especiallyamongyoungerchildren.Futurestudiesshouldassesstheacceptabilityofthistreatmentamongchildrenandtheirparents.

Finally,wedidnotcomparethistreatmenttootherapproaches,suchastraditionaloralantihistaminesorintranasalcorticosteroids,whicharecommonlyusedtotreatnasalcongestioninchildrenwithallergies.AcomparisonbetweentheefficacyandsafetyofthisalternativetherapyandothertreatmentswouldprovidevaluableinsightsintothebestmanagementoptionsforchildrenwithShaoyaoallergy.

Inconclusion,ourstudyprovidespreliminaryevidencetosupporttheuseofShaoyaoallergydecoctionandCangerzioilforthetreatmentofnasalcongestioninchildrenwithShaoyaoallergy.Furtherstudiesareneededtoconfirmourfindingsandassesstheacceptabilityandlong-termsafetyofthisalternativetherapy.Inlightofthelackofeffectiveandsafetreatmentsforthiscondition,ourresultsprovidehopeforfamiliesandcliniciansmanagingthischallengingconditionInadditiontothetreatmentofShaoyaoallergy,itisimportanttoconsidermeasuresforpreventionandmanagementofthiscondition.ParentsofchildrenwithahistoryofShaoyaoallergyshouldbeadvisedtoavoidusingtheherbanditsderivatives,anddisclosethisinformationtohealthcareproviders.Similarly,healthcarepractitionersshouldbevigilantforShaoyaoallergyinchildrenandinquireabouttheuseofherbalremediesintheirhistory.

Educationontherisksandbenefitsofherbalremediesamonghealthcareprovidersandthepublicmayalsobebeneficialinpreventingadversereactions.Governmentregulationsandmonitoringofthequalityofherbalsupplementsmayalsobenecessarytoensuretheirsafety.

Moreover,moreresearchisneededtounderstandtheunderlyingmechanismsofShaoyaoallergyandtoidentifypotentialbiomarkerstopredictsusceptibilitytothiscondition.ThismayleadtothedevelopmentoftargetedtherapiesandpersonalizedmedicineforShaoyaoallergy.

Insummary,Shaoyaoallergyisararebutpotentiallyseriousconditionthatwarra