骨科植入物局部生命化

骨科植入物局部生命化上海交通大學(xué)機械與動力工程學(xué)院生物醫(yī)學(xué)制造與生命質(zhì)量工程研究所骨科植入物的類型脊柱類關(guān)節(jié)類創(chuàng)傷類CombustorLinerRobotArmAcetabularCupBlastResistantPanel金屬3D打印技術(shù)標(biāo)準(zhǔn)系列產(chǎn)品多孔鈦合金個體化植入物個體化植入物金屬3D打印技術(shù)開辟了骨科植入技術(shù)的新紀(jì)元以激光為能量源以電子束為能量源金屬3D打印技術(shù)金屬3D打印技術(shù)德國ConceptLaserM2激光熔融成型技術(shù)（SelectiveLaserMelting,SLM）瑞典ArcamA1電子束熔化成型技術(shù)（ElectronBeamMelting,EBM）高孔隙桿系結(jié)構(gòu)模型，設(shè)計孔隙率93.61%八面體嵌套結(jié)構(gòu)模型，設(shè)計孔隙率91.48%蜂窩狀結(jié)構(gòu)模型，設(shè)計孔隙率89.72%孔隙結(jié)構(gòu)設(shè)計正六面體嵌套結(jié)構(gòu)模型，設(shè)計孔隙率93.53%交叉曲面結(jié)構(gòu)模型，設(shè)計孔隙率88.87%正交結(jié)構(gòu)模型，設(shè)計孔隙率86.5%材料：不銹鋼鈦及其合金鈷鉻鉬合金粉體尺寸：45-100μm(EBM)20-30μm(SLM)金屬3D打印制造高孔隙桿系結(jié)構(gòu)模型八面體嵌套結(jié)構(gòu)模型蜂窩狀結(jié)構(gòu)模型正交結(jié)構(gòu)模型正六面體嵌套結(jié)構(gòu)模型交叉曲面結(jié)構(gòu)模型多孔鈦合金結(jié)構(gòu)體孔隙結(jié)構(gòu)特征XiangLi*,etal.Materialsletters2009;63:403-405.XiangLi*,etal.Proc.IMechEPartH:J.EngineeringinMedicine,223:173-178,2009.XiangLi*,etal.RapidPrototypingJournal,16:44-49,2010.EBM技術(shù)制造SLM技術(shù)制造仿生結(jié)構(gòu)模型孔隙結(jié)構(gòu)特征EBM技術(shù)制造SLM技術(shù)制造孔隙結(jié)構(gòu)特征孔隙率：66-88%孔的尺寸：415-672μm桿的長度：224±43μm桿的寬度：67-187μmShimkoDA,etal.EffectofPorosityontheFluidFlowCharacteristicsandMechanicalPropertiesofTantalumScaffolds.JBiomedMaterResPartB:ApplBiomater73B:315–324,2005孔隙結(jié)構(gòu)特征多孔鉭（Zimmer）力學(xué)性能測試多孔鈦P（%）65-73Zimmer63-68ActiporeSevillaP,AparicioC,PlanellJA,GilFJ.Comparisonofthemechanicalpropertiesbetweentantalumandnickel–titaniumfoamsimplantmaterialsforboneingrowthapplications.JournalofAlloysandCompounds439(2007)67–73.彈性模量E(GPa)屈服強度σo(MPa)抗壓強度σmax(MPa)孔隙率(%)1.7343.655.5851.8654.866.5813.8598.6125.8733.98155.3185.9674.72163.7197.46210-30104-121193-205Corticalbone表面改性多孔鈦在SBF模擬體液中浸泡14天SEMmorphologiesofcellsonporoustitaniumsamplesafter14daysofculture.(A–B)pureporoustitaniumscaffoldsand(C–D)poroustitaniumscaffoldswithbiomimeticcoating體外細胞培養(yǎng)Cellviabilityofthesampleover14daysofinvitroculture動物實驗植入兔顱骨4、8和12周后取樣Histologicalstainingforosteogenesiswithinporoustitaniumafterimplantationfor4,8and12weeks.Ti:pureporousTi,TiC:biomimeticcoatedporousTi4W×168W×1612W×1612W×100TiTiC動物實驗HistomorphometricanalysisofnewboneformationXiangLi,etal.EvaluationofBiologicalPropertiesofElectronBeamMeltedTi6Al4VImplantwithBiomimeticCoatinginVitroandInVivo.PLoSONE2012;

7(12):e52049.動物實驗利用化學(xué)氣相沉積法制備鉭涂層鉭涂層制備方法鉭涂層多孔鈦體外細胞培養(yǎng)實驗多孔鈦支架鉭涂層支架體外細胞培養(yǎng)實驗動物實驗Representativehistologicalsectionsofporousimplantsafter12weeksofimplantationinthecristailiacaofgoats.(a–c)Uncoatedand(d–f)Ta-coatedimplants.動物實驗ResultsofhistomorphometricalanalysesofuncoatedandTa-coatedXiangLi,etal.TantalumcoatingonporousTi6Al4Vscaffoldusingchemicalvapordepositionandpreliminarybiologicalevaluation.MaterialsScienceandEngineeringC2013;33:2987–2994.與組織工程相結(jié)合骨誘導(dǎo)生物材料﹢多孔鈦合金﹢干細胞/BMP多孔鈦合金承載體組織工程復(fù)合多孔支架多孔鈦合金支架聚合物海綿優(yōu)異的力學(xué)性能組織親和性PorousTiSoakedinpolymersolutionTi/polymerconstructPorouscompositescaffoldFreezingLyophilization復(fù)合型骨修復(fù)體3DPrintingFreeze-dryingGoodMechanicalPropertiesFavorableCellAffinityalginateChitosanChitosan/HAChitosan微觀結(jié)構(gòu)XiangLi,YunLuo,ChengtaoWang.PreparationandcharacterizationofporousTi6Al4V/alginatehybridimplantbycombinationofelectronbeammeltingandfreeze-drying.MaterialsLetters,2012;81:23-26.MicrostructureofTi6Al4V/silkfibroincompositescaffold體外細胞培養(yǎng)實驗PureTiTi+ChsTi+Chs+HAPureTiTi+ChsTi+Chs+HACellmorphologyonscaffoldsfor7and14days動物實驗羊髂骨缺損12周取樣動物實驗動物實驗小結(jié)金屬3D