Ulipristal-CDB-3236-DataSheet-生命科學試劑-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEUlipristalCat.No.:HY-14959CASNo.:159811-51-5Synonyms:CDB-3236;DeacetylCDB-2914分?式:C??H??NO?分?量:433.58作?靶點:ProgesteroneReceptor作?通路:Others儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:≥250mg/mL(576.59mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.3064mL11.5319mL23.0638mL5mM0.4613mL2.3064mL4.6128mL10mM0.2306mL1.1532mL2.3064mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；澄的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥6.25mg/mL(14.41mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥6.25mg/mL(14.41mM);Clearsolution1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性Ulipristal(CDB3236)?種選擇性的性孕酮受體(progesteronereceptor)調節(jié)劑。Ulipristal與孕激素受體結合，從?抑制PR介導的因表達，并?擾?殖系統(tǒng)中孕激素的活性。體內(nèi)研究Ulipristal(CDB3236)maysuppressthegrowthofuterineleiomyomatosis.Byinhibitingordelayingovulationandeffectingendometrialtissue,ulipristalcanbeusedasanemergencycontraception[1].REFERENCES[1].LIANAPLES,etal.IsUlipristalAcetateaLiverToxicBiomolecule?Toxicityassessmentofulipristalacetate.REV.CHIM.(Bucharest).McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559