Oxprenolol-hydrochloride-Ba-39089-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEOxprenololhydrochlorideCat.No.:HY-B1486CASNo.:6452-73-9Synonyms:Ba39089分?式:C??H??ClNO?分?量:301.81作?靶點(diǎn):AdrenergicReceptor作?通路:GPCR/GProtein;NeuronalSignaling儲存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:250mg/mL(828.34mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.3133mL16.5667mL33.1334mL5mM0.6627mL3.3133mL6.6267mL10mM0.3313mL1.6567mL3.3133mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(6.89mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(6.89mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(6.89mM);Clearsolution1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性O(shè)xprenololhydrochloride(Ba39089)?種?服有效的β-腎上腺素受體(β-AR)拮抗劑，Ki為7.10nM[1]。IC50&TargetKi:7.10nM(β-adrenergicreceptor)[1]體內(nèi)研究Oxprenolol(200mg/kg/day;administeredorally;for3weeks)produceseffectivebeta-blockade[2].AnimalModel:Malerats(230to300gbodywt)oftheWistarstrain[2]Dosage:200mg/kgAdministration:Administeredorally;dailyfor3weeksResult:Thisdosageproducedeffectivebeta-blockade.REFERENCES[1].TNagatomo,etal.BindingCharacteristicsofH-dihydroalprenololtoBeta-AdrenoceptorsofRatHeartTreatedWithNeuraminidase.JpnJPharmacol.1983Aug;33(4):851-7.[2].ASManning,etal.AbruptWithdrawalofChronicBeta-Blockade:AdaptiveChangesinCyclicAMPandContractility.JMolCellCardiol.1981Nov;13(11):999-1009.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-