MLS000532223-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEMLS000532223Cat.No.:HY-117149CASNo.:16616-39-0分?式:C??H?NO?分?量:251.24作?靶點:Ras作?通路:GPCR/GProtein儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:50mg/mL(199.01mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.9803mL19.9013mL39.8026mL5mM0.7961mL3.9803mL7.9605mL10mM0.3980mL1.9901mL3.9803mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。BIOLOGICALACTIVITY?物活性MLS000532223?種選擇性的，具有?親和?的Rho家族GTPases(RhofamilyGTPases)抑制劑，其EC50范為16-120μM。MLS000532223能阻?GTP與?種GTPases相結合。?GTPases細胞活性的關鍵調節(jié)因?[1]。IC50&TargetEC50:16-120μM(RhofamilyGTPases)[1]體外研究MLS000532223preventsGTPbindingtoseveralGTPasesinadose-dependentmanner[1].1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEMLS000532223modulatesRho-familyGTP-bindingkinetics[1].MLS000532223isactiveincell–basedassaysandinhibitsEGF-stimulatedRac1activation[1].MLS000532223inhibitsactinrearrangementsandchangesincellmorphologythataredownstreamofRhofamilyGTPaseactivation[1].MLS000532223(10μM)modulatesactinremodelinginmastcells[1].MLS000532223(10μM)inhibitsligand-stimulatedβ-hexosaminidasesecretionofRBLcells[1].REFERENCES[1].ZurabSurviladze,etal.IdentificationofaSmallGTPaseInhibitorUsingaHigh-ThroughputFlowCytometryBead-BasedMultiplexAssay.JBiomolScreen.2010Jan;15(1):10-20.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895